ArticleMolecular psychiatry2005
Catechol-O-methyl transferase Val158Met gene polymorphism in schizophrenia: working memory, frontal lobe MRI morphology and frontal cerebral blood flow.
Article in Molecular psychiatry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
75 citing papers in PubMed, 4 syntheses or guidelines pooled it, 195 citations in OpenAlex.
- The Role of a Catechol-O-Methyltransferase (COMT) Val158Met Genetic Polymorphism in Schizophrenia: A Systematic Review and Updated Meta-analysis on 32,816 Subjects.Neuromolecular medicine · 2016Pooled it
- COMT, neuropsychological function and brain structure in schizophrenia: a systematic review and neurobiological interpretation.Journal of psychiatry & neuroscience : JPN · 2013Pooled it
- Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls.Molecular psychiatry · 2007Pooled it
- Overlap between genetic variants associated with schizophrenia spectrum disorders and intelligence quotient: a systematic review.Journal of psychiatry & neuroscience : JPNPooled it
- Negative Symptoms and Their Associations With Other Clinical Variables and Working Memory Across the Schizophrenia Spectrum and Bipolar Disorder.Schizophrenia bulletin open · 2024Article
- The role of genetic polymorphisms in executive functioning performance in temporal lobe epilepsy.Epilepsy & behavior : E&B · 2021Article
- Genetics of schizophrenia (Review).Experimental and therapeutic medicine · 2020Review
- Assessing auditory processing endophenotypes associated with Schizophrenia in individuals with 22q11.2 deletion syndrome.Translational psychiatry · 2020Article
- Article
- Memory and cognition in schizophrenia.Molecular psychiatry · 2019Review
- Imaging Genetics Towards a Refined Diagnosis of Schizophrenia.Frontiers in psychiatry · 2019Review
- COMT polymorphism regulates the hippocampal subfield volumes in first-episode, drug-naive patients with major depressive disorder.Neuropsychiatric disease and treatment · 2019Article
- Heritability and genome-wide associations studies of cerebral blood flow in the general population.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Article
- Mapping the Schizophrenia Genes by Neuroimaging: The Opportunities and the Challenges.International journal of molecular sciences · 2018Review
- Sex-specific effects ofBrain and behavior · 2017Article
- COMT ValJournal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2017Observational
- Age-Dependent Effects of Catechol-O-Methyltransferase (COMT) Gene Val158Met Polymorphism on Language Function in Developing Children.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Genetic predictor of working memory and prefrontal function in women with HIV.Journal of neurovirology · 2015Article
- Imaging genetics and psychiatric disorders.Current molecular medicine · 2015Review
- Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The catechol-O-methyl transferase (COMT) gene is considered a leading schizophrenia candidate gene. Although its role in increasing schizophrenia susceptibility has been conflicting, recent studies suggest the valine allele may contribute to poor cognitive function in schizophrenia. V(158)M COMT genotype was obtained on 159 schizophrenia patients and 84 healthy controls. The effects of COMT genotype on four measures of working memory/executive functions (Wisconsin Card Sorting, digit span backward, Trail Making and N-back tests) and on MRI frontal brain volumes were examined. Genotype distributions were not significantly different between patients and controls. There were no significant genotype or genotype-by-group effects on any working memory/executive function measures. No genotype or genotype-by-diagnosis interaction effects were found with MRI frontal lobe volumes. Randomization analyses using [(15)O]H(2)O positron emission tomography (PET) cerebral blood flow data found Val/Val patients had higher frontal lobe activation than Met/Met patients while performing the one-back task. Overall, these findings do not support a major role for COMT in increasing susceptibility for schizophrenia or in mediating frontal lobe function. Age-related changes and phenotypic heterogeneity of schizophrenia may influence the complex relationships between COMT genotype and cognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.