ArticleBritish journal of cancer2005
Invasive characteristics of human prostatic epithelial cells: understanding the metastatic process.
Article in British journal of cancer, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Non-canonical EphA2 activation underpins PTEN-mediated metastatic migration and poor clinical outcome in prostate cancer.British journal of cancer · 2022Article
- Role of stromal cell-derived factor 1α pathway in bone metastatic prostate cancer.Journal of biomedical research · 2016Review
- Vasculogenic Mimicry in Prostate Cancer: The Roles of EphA2 and PI3K.Journal of Cancer · 2016Article
- Stromal-derived factor-1α/CXCL12-CXCR4 chemotactic pathway promotes perineural invasion in pancreatic cancer.Oncotarget · 2015Article
- Altered gene products involved in the malignant reprogramming of cancer stem/progenitor cells and multitargeted therapies.Molecular aspects of medicine · 2014Review
- Arachidonic acid induction of Rho-mediated transendothelial migration in prostate cancer.British journal of cancer · 2014Article
- Co-expression of uPAR and CXCR4 promotes tumor growth and metastasis in small cell lung cancer.International journal of clinical and experimental pathology · 2014Article
- Ligand-independent activation of EphA2 by arachidonic acid induces metastasis-like behaviour in prostate cancer cells.British journal of cancer · 2012Article
- Attenuation of osteoarthritis via blockade of the SDF-1/CXCR4 signaling pathway.Arthritis research & therapy · 2012Article
- The differential effects of statins on the metastatic behaviour of prostate cancer.British journal of cancer · 2012Article
- Evaluation of nuclear factor κB and chemokine receptor CXCR4 co-expression in patients with prostate cancer in the Radiation Therapy Oncology Group (RTOG) 8610.BJU international · 2011Article
- Steps in prostate cancer progression that lead to bone metastasis.International journal of cancer · 2011Review
- Influence of omega-6 PUFA arachidonic acid and bone marrow adipocytes on metastatic spread from prostate cancer.British journal of cancer · 2010Article
- Cranberry proanthocyanidins are cytotoxic to human cancer cells and sensitize platinum-resistant ovarian cancer cells to paraplatin.Phytotherapy research : PTR · 2009Article
- Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate.Nature genetics · 2009Article
- Chemokine receptor CXCR4 as a therapeutic target for neuroectodermal tumors.Seminars in cancer biology · 2009Review
- Review
- Molecular mechanisms of metastasis in prostate cancer.Asian journal of andrology · 2009Review
- CXCR4-gp120-IIIB interactions induce caspase-mediated apoptosis of prostate cancer cells and inhibit tumor growth.Molecular cancer therapeutics · 2009Article
- Modulation of prostate cancer cell gene expression by cell-to-cell contact with bone marrow stromal cells or osteoblasts.Clinical & experimental metastasis · 2009Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prostate cancer has a predilection to metastasise to the bone marrow stroma (BMS) by an as yet uncharacterised mechanism. We have defined a series of coculture models of invasion, which simulate the blood/BMS boundary and allow the elucidation of the signalling and mechanics of trans-endothelial migration within the complex bone marrow environment. Confocal microscopy shows that prostate epithelial cells bind specifically to bone marrow endothelial-to-endothelial cell junctions and initiate endothelial cell retraction. Trans-endothelial migration proceeds via an epithelial cell pseudopodial process, with complete epithelial migration occurring after 232+/-43 min. Stromal-derived factor-1 (SDF-1)/CXCR4 signalling induced PC-3 to invade across a basement membrane although the level of invasion was 3.5-fold less than invasion towards BMS (P=0.0007) or bone marrow endothelial cells (P=0.004). Maximal SDF-1 signalling of invasion was completely inhibited by 10 microM of the SDF-1 inhibitor T140. However, 10 microM T140 only reduced invasion towards BMS and bone marrow endothelial cells by 59% (P=0.001) and 29% (P=0.011), respectively. This study highlights the need to examine the potential roles of signalling molecules and/or inhibitors, not just in single-cell models but in coculture models that mimic the complex environment of the bone marrow.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.