ArticleThe Journal of cell biology2005
X chromosome choice occurs independently of asynchronous replication timing.
Article in The Journal of cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- RNA sequencing provides functional insights and diagnostic resolution in previously unsolved rare disease cases.BMC medical genomics · 2025Article
- Escape from X-chromosome inactivation at KDM5C is driven by promoter-proximal DNA elements and enhanced by domain context.Human molecular genetics · 2025Article
- Asynchronous Replication Timing: A Mechanism for Monoallelic Choice During Development.Frontiers in cell and developmental biology · 2021Review
- The X Files: "The Mystery of X Chromosome Instability in Alzheimer's Disease".Frontiers in genetics · 2019Review
- Allele-specific control of replication timing and genome organization during development.Genome research · 2018Article
- Human cis-acting elements regulating escape from X-chromosome inactivation function in mouse.Human molecular genetics · 2018Article
- Round Spermatid Injection Rescues Female Lethality of a Paternally Inherited Xist Deletion in Mouse.PLoS genetics · 2016Article
- Sex-specific silencing of X-linked genes by Xist RNA.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Dynamics of gene silencing during X inactivation using allele-specific RNA-seq.Genome biology · 2015Article
- Independent recruitment of Igh alleles in V(D)J recombination.Nature communications · 2014Article
- Structural and numerical changes of chromosome X in patients with esophageal atresia.European journal of human genetics : EJHG · 2014Article
- Combined DNA-RNA fluorescent in situ hybridization (FISH) to study X chromosome inactivation in differentiated female mouse embryonic stem cells.Journal of visualized experiments : JoVE · 2014Article
- Targeting of >1.5 Mb of human DNA into the mouse X chromosome reveals presence of cis-acting regulators of epigenetic silencing.Genetics · 2012Article
- Article
- Genomic imprinting and epigenetic control of development.Cold Spring Harbor perspectives in biology · 2012Article
- Late-replicating heterochromatin is characterized by decreased cytosine methylation in the human genome.Genome research · 2011Article
- CTCF regulates the local epigenetic state of ribosomal DNA repeats.Epigenetics & chromatin · 2010Article
- The A-repeat links ASF/SF2-dependent Xist RNA processing with random choice during X inactivation.Nature structural & molecular biology · 2010Article
- Allelic inactivation of rDNA loci.Genes & development · 2009Article
- X-chromosome inactivation: the molecular basis of silencing.Journal of biology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
In mammals, dosage compensation is achieved by X chromosome inactivation in female cells. Xist is required and sufficient for X inactivation, and Xist gene deletions result in completely skewed X inactivation. In this work, we analyzed skewing of X inactivation in mice with an Xist deletion encompassing sequence 5 KB upstream of the promoter through exon 3. We found that this mutation results in primary nonrandom X inactivation in which the wild-type X chromosome is always chosen for inactivation. To understand the molecular mechanisms that affect choice, we analyzed the role of replication timing in X inactivation choice. We found that the two Xist alleles and all regions tested on the X chromosome replicate asynchronously before the start of X inactivation. However, analysis of replication timing in cell lines with skewed X inactivation showed no preference for one of the two Xist alleles to replicate early in S-phase before the onset of X inactivation, indicating that asynchronous replication timing does not play a role in skewing of X inactivation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.