Evidence map›Paper›PMID 15668127›Full record

ReviewTrends in immunology2005

Sinks, suppressors and antigen presenters: how lymphodepletion enhances T cell-mediated tumor immunotherapy.

Christopher A Klebanoff, Hung T Khong, Paul A Antony, Douglas C Palmer, Nicholas P Restifo

Erratum issuedAbstract readReview
In one paragraph

Review in Trends in immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 250 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
250citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

250 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Trial
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  12. Article
  13. Review
  14. Article
  15. Article
  16. Technical review of artificial intelligence in TCR-T therapy.Journal of the National Cancer Center · 2026
    Review
  17. Article
  18. Article
  19. Review
  20. Review

190 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

5 authors.

Christopher A KlebanoffHoward Hughes Medical Institute-National Institutes of Health Research Scholars Program, Bethesda, MD 20814, USA.
Hung T Khong
Paul A Antony
Douglas C Palmer
Nicholas P Restifo

Funding

Building on the success of the adoptive immunotherapy of cancerZ01BC010763 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI RESTIFO, NICHOLAS P · 2006 to 2008
$6.4M
RECOMBINANT AND SYNTHETIC ANTI-CANCER VACCINESZ01SC006670 · SC · CLINICAL SCIENCES · PI RESTIFO, NICHOLAS P · 1996 to 2005
–
Intramural NIH HHS Z01 BC010763Intramural NIH HHS Z99 CA999999
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Immunotherapy, AdoptiveLymphocyte DepletionAnimalsAntigen-Presenting CellsClinical Trials as TopicHumansImmune ToleranceInterleukin Receptor Common gamma SubunitInterleukinsLymphocyte ActivationModels, ImmunologicalNeoplasmsReceptors, Interleukin-7T-LymphocytesTreatment OutcomeIL2RG protein, humanInterleukin Receptor Common gamma SubunitInterleukinsReceptors, Interleukin-7

Identifiers

PMID15668127
PMCPMC1388277

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.