ReviewImmunology2005
V(H) replacement in rearranged immunoglobulin genes.
Review in Immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Multiple productive immunoglobulin heavy chain gene rearrangements in chronic lymphocytic leukemia are mostly derived from independent clones.Haematologica · 2014Trial
- Receptor editing constrains development of phosphatidyl choline-specific B cells in VCell reports · 2022Article
- Identifying IGH disease clones for MRD monitoring in childhood B-cell acute lymphoblastic leukemia using RNA-Seq.Leukemia · 2020Article
- Minimal Residual Disease Detection and EvolvedFrontiers in immunology · 2016Article
- Article
- Article
- Trials and Tribulations with VH Replacement.Frontiers in immunology · 2014Review
- Immunologic Basis for Long HCDR3s in Broadly Neutralizing Antibodies Against HIV-1.Frontiers in immunology · 2014Review
- Erroneous class switching and false VDJ recombination: molecular dissection of t(8;14)/MYC-IGH translocations in Burkitt-type lymphoblastic leukemia/B-cell lymphoma.Molecular oncology · 2013Article
- Secondary mechanisms of diversification in the human antibody repertoire.Frontiers in immunology · 2013Article
- Patterns of receptor revision in the immunoglobulin heavy chains of a teleost fish.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Non-conservative homologous recombination in human B lymphocytes is promoted by activation-induced cytidine deaminase and transcription.Nucleic acids research · 2008Article
- Multiple, conserved cryptic recombination signals in VH gene segments: detection of cleavage products only in pro B cells.The Journal of experimental medicine · 2007Article
- Immunoglobulin kappa enhancers are differentially regulated at the level of chromatin structure.Molecular immunology · 2007Article
- Gene conversion in human rearranged immunoglobulin genes.Immunogenetics · 2006Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Examples suggesting that all or part of the V(H) segment of a rearranged V(H)DJ(H) may be replaced by all or part of another V(H) have been appearing since the 1980s. Evidence has been presented of two rather different types of replacement. One of these has gained acceptance and has now been clearly demonstrated to occur. The other, proposed more recently, has not yet gained general acceptance because the same effect can be produced by polymerase chain reaction artefact. We review both types of replacement including a critical examination of evidence for the latter. The first type involves RAG proteins and recombination signal sequences (RSS) and occurs in immature B cells. The second was also thought to be brought about by RAG proteins and RSS. However, it has been reported in hypermutating cells which are not thought to express RAG proteins but in which activation-induced cytidine deaminase (AID) has recently been shown to initiate homologous recombination. Re-examination of the published sequences reveals AID target sites in V(H)-V(H) junction regions and examples that resemble gene conversion.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.