ArticleCellular and molecular life sciences : CMLS2005
Oestrogen-modulated gene expression in the human endometrium.
Article in Cellular and molecular life sciences : CMLS, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 100 citations in OpenAlex.
- Endometrial receptivity: a revisit to functional genomics studies on human endometrium and creation of HGEx-ERdb.PloS one · 2013Trial
- A cell atlas of the human fallopian tube throughout the menstrual cycle and menopause.Nature communications · 2025Article
- Uterine cyclin A2-deficient mice as a model of female early pregnancy loss.The Journal of clinical investigation · 2024Article
- Genome-wide association study for stayability at different calvings in Nellore beef cattle.BMC genomics · 2024Article
- Deciphering a shared transcriptomic regulation and the relative contribution of each regulator type through endometrial gene expression signatures.Reproductive biology and endocrinology : RB&E · 2023Article
- Review
- Human Endometrial Organoids: Recent Research Progress and Potential Applications.Frontiers in cell and developmental biology · 2022Review
- The role of epigenetic mechanisms in the regulation of gene expression in the cyclical endometrium.Clinical epigenetics · 2021Review
- Endometrial Receptivity Analysis (ERA): data versus opinions.Human reproduction open · 2021Article
- Genetic Regulation of Transcription in the Endometrium in Health and Disease.Frontiers in reproductive health · 2021Review
- Genetic regulation of disease risk and endometrial gene expression highlights potential target genes for endometriosis and polycystic ovarian syndrome.Scientific reports · 2018Article
- Reduced homeobox protein MSX1 in human endometrial tissue is linked to infertility.Human reproduction (Oxford, England) · 2016Article
- Dose- and Time-Dependent Transcriptional Response of Ishikawa Cells Exposed to Genistein.Toxicological sciences : an official journal of the Society of Toxicology · 2016Article
- Changes in receptivity epithelial cell markers of endometrium after ovarian stimulation treatments: its role during implantation window.Reproductive health · 2015Article
- Human Endometrial Transcriptomics: Implications for Embryonic Implantation.Cold Spring Harbor perspectives in medicine · 2015Review
- Two methods for establishing primary human endometrial stromal cells from hysterectomy specimens.Journal of visualized experiments : JoVE · 2014Article
- Changes in mouse uterine transcriptome in estrus and proestrus.Biology of reproduction · 2013Article
- Flotillin2 expression correlates with HER2 levels and poor prognosis in gastric cancer.PloS one · 2013Article
- High throughput, cell type-specific analysis of key proteins in human endometrial biopsies of women from fertile and infertile couples.Human reproduction (Oxford, England) · 2012Article
- Bioinformatic detection of E47, E2F1 and SREBP1 transcription factors as potential regulators of genes associated to acquisition of endometrial receptivity.Reproductive biology and endocrinology : RB&E · 2011Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To identify key regulatory mechanisms in the growth and development of the human endometrium, microarray analysis was performed on uncultured human endometrium collected during menstruation (M) and the late-proliferative (LATE-P)-phase of the menstrual cycle, as well as after 24 h incubation in the presence of oestradiol (17beta-E2). We demonstrate the expression of novel gene transcripts in the human endometrium. i.e. mucin-9, novel oestrogen-responsive gene transcripts, i.e. gelsolin and flotillin-1, and genes known to be expressed in human endometrium but not yet shown to be oestrogen responsive, i.e. connexin-37 and TFF1/pS2. Genes reported to be expressed during the implantation window and implicated in progesterone action, i.e. secretoglobin family 2A, member 2 (mammaglobin) and homeobox-containing proteins, were up-regulated in uncultured LATE-P-phase endometrium compared to M-phase endometrium. Some gene transcripts are regulated directly by 17beta-E2 alone, others are influenced by the in vivo environment as well. These observations emphasise that the regulation of endometrium maturation by oestrogen entails more then just stimulation of cell proliferation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.