Trial reportClinical autonomic research : official journal of the Clinical Autonomic Research Society2004
Effect of local heating and vasodilation on the cutaneous venoarteriolar response.
Trial report in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Peripheral Microvascular Vasodilatory Response to Estradiol and Genistein in Women with Insulin Resistance.Microcirculation (New York, N.Y. : 1994) · 2015Trial
- Sustained sitting attenuates cutaneous reactive hyperemia while improving venoarteriolar reflex, and alternating ambient exposure to cool and heat does not modulate these responses.European journal of applied physiology · 2025Article
- Revisiting the Venoarteriolar Reflex-Further Insights from Upper Limb Dependency in Healthy Subjects.Biology · 2024Article
- In vivo pressure-flow relation of human cutaneous vessels following prolonged iterative exposures to hypergravity.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Effect of reflex and mechanical decreases in skin perfusion on thermal- and agonist-induced eccrine sweating in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Mechanisms of Venoarteriolar Reflex in Type 2 Diabetes with or without Peripheral Neuropathy.Biology · 2021Article
- Thermal Assisted In Vivo Gene Electrotransfer.Current gene therapy · 2016Article
- Age- and limb-related differences in the vasoconstrictor response to limb dependency are not mediated by a sympathetic mechanism in humans.Acta physiologica (Oxford, England) · 2012Article
- Pharmacological curve fitting to analyze cutaneous adrenergic responses.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Article
- Effect of whole body heat stress on peripheral vasoconstriction during leg dependency.Journal of applied physiology (Bethesda, Md. : 1985) · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cutaneous venoarteriolar response (CVAR) is a local non-adrenergic vasoconstrictor reflex that is engaged via increases in local transmural pressure. The purpose of this study was to determine if local temperature alters the vasoconstrictor ability of the CVAR. Twelve (5 male, 7 female) subjects performed a CVAR maneuver at local temperatures of 30+/-1, 34, 38, and 42 degrees C. CVAR was also engaged after vasodilation via intradermal perfusion of sodium nitroprusside or the attenuation of local heating-induced vasodilation via intradermal perfusion of N(G)-nitro-L: -arginine methyl ester (L: -NAME) in five subjects (2 male, 3 female). CVAR was elicited by rapid cuff inflation to 45mmHg proximal to two dorsal forearm sites for 2 min in both protocols. Local heating caused a progressive increase in skin blood flow (8+/-1, 18+/-4, 43+/-11, and 78+/-2% maximal skin blood flow for 30+/-1, 34, 38, and 42 degrees C, respectively). Engagement of the CVAR decreased skin blood flow by 53+/-2, 57+/-3, and 51+/-4%, for 30+/-1, 34, and 38 degrees C, respectively. In contrast, local heating to 42 degrees C significantly attenuated the CVAR (16+/-11 %). Local administration of sodium nitroprusside during neutral temperature and L: -NAME during local heating also significantly attenuated the vasoconstrictor response of the CVAR by 27+/-8 and 38+/-4%, respectively. These data indicate that CVAR is attenuated at high (42 degrees C) local skin temperatures and that this attenuation is likely due to an effect of both local heating-induced vasodilation and a direct temperature effect.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.