ReviewBone marrow transplantation2005
In utero transplantation: baby steps towards an effective therapy.
Review in Bone marrow transplantation, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 48 citations in OpenAlex.
- Production of factor VIII by human liver sinusoidal endothelial cells transplanted in immunodeficient uPA mice.PloS one · 2013Trial
- Transplanting FVIII/ET3-secreting cells in fetal sheep increases FVIII levels long-term without inducing immunity or toxicity.Nature communications · 2023Article
- Immunological Consequences ofFrontiers in immunology · 2021Review
- In utero xenotransplantation of mice bone marrow-derived stromal/stem cells into fetal rat liver: An experimental study.International journal of reproductive biomedicine · 2020Article
- Application potential of bone marrow mesenchymal stem cell (BMSCs) based tissue-engineering for spinal cord defect repair in rat fetuses with spina bifida aperta.Journal of materials science. Materials in medicine · 2016Article
- Progress and challenges in the development of a cell-based therapy for hemophilia A.Journal of thrombosis and haemostasis : JTH · 2014Review
- Temporal definition of haematopoietic stem cell niches in a large animal model of in utero stem cell transplantation.British journal of haematology · 2014Article
- In utero therapy for congenital disorders using amniotic fluid stem cells.Frontiers in pharmacology · 2014Article
- In utero hematopoietic cell transplantation: induction of donor specific immune tolerance and postnatal transplants.Frontiers in pharmacology · 2014Review
- Therapeutic potential of in utero mesenchymal stem cell (MSCs) transplantation in rat foetuses with spina bifida aperta.Journal of cellular and molecular medicine · 2012Article
- Fetal liver-derived mesenchymal stem cell engraftment after allogeneic in utero transplantation into rabbits.Stem cells and development · 2012Article
- Cellular therapies supplement: the peritoneum as an ectopic site of hematopoiesis following in utero transplantation.Transfusion · 2011Article
- Immunoresponse against the transgene limits hematopoietic engraftment of mice transplanted in utero with virally transduced fetal liver.Gene therapy · 2011Article
- Genetics of SCID.Italian journal of pediatrics · 2010Review
- Article
- Fetal stem cells from extra-embryonic tissues: do not discard.Journal of cellular and molecular medicine · 2008Review
- Article
- In utero transplantation: baby steps towards an effective therapy.Bone marrow transplantation · 2005Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
In utero transplantation (IUT) offers the potential to treat a large number of diseases by transplantation of healthy cells into a fetus with a birth defect. Prenatal diagnosis is feasible for many diseases prior to the full development of the fetal immune system offering the opportunity to introduce foreign cells and antigens into the developing fetus. At least 45 cases of IUT have been performed for a variety of diseases. IUT has successfully treated severe combined immunodeficiency and there are indications that it may be effective in treating some nonhematopoietic diseases. However, many diseases remain resistant to fetal therapy owing to the low levels of chimerism that can be achieved. Promising efforts to improve the levels of engraftment are focusing on optimizing the graft and developing donor-specific tolerance in the fetal recipient. Mounting evidence suggests that donor T cells can aid in achieving clinically significant levels of chimerism. The use of fetal donor cells may also offer some benefit. Animal experiments suggest that even low-level chimerism can lead to tolerance, which can be exploited by booster transplants in the neonate. Continued research appears likely to succeed in developing IUT into an effective form of therapy for a variety of diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.