Trial reportThe British journal of ophthalmology2005
Multifocal electroretinogram in children on atropine treatment for myopia.
Trial report in The British journal of ophthalmology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 6 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Interventions for myopia control in children: a living systematic review and network meta-analysis.The Cochrane database of systematic reviews · 2025Pooled it
- Interventions for myopia control in children: a living systematic review and network meta-analysis.The Cochrane database of systematic reviews · 2023Pooled it
- Varying Dose of Atropine in Slowing Myopia Progression in Children Over Different Follow-Up Periods by Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Interventions to slow progression of myopia in children.The Cochrane database of systematic reviews · 2020Pooled it
- A Review of Current Concepts of the Etiology and Treatment of Myopia.Eye & contact lens · 2018Pooled it
- Interventions to slow progression of myopia in children.The Cochrane database of systematic reviews · 2011Pooled it
- Efficacy of 0.01% atropine for myopia control in a randomized, placebo-controlled trial depends on baseline electroretinal response.Scientific reports · 2022Trial
- Effect of 0.02% and 0.01% atropine on astigmatism: a two-year clinical trial.BMC ophthalmology · 2022Trial
- Full-field electroretinogram findings in children in the atropine treatment for myopia (ATOM2) study.Documenta ophthalmologica. Advances in ophthalmology · 2013Trial
- Short-Term Changes in Retinal Activity With Four Myopia Control Spectacle Lenses.Translational vision science & technology · 2026Article
- Sustained Experimental Myopia Exacerbates the Effect of Eye Growth on Retinal Ganglion Cell Density and Function.International journal of molecular sciences · 2025Article
- Low concentration atropine and myopia: a narrative review of the evidence for United Kingdom based practitioners.Eye (London, England) · 2024Review
- Retardation of myopia by atropine regimes.International journal of ophthalmology · 2024Review
- The Preventive Role of Atropine Eye Drops on Myopia Progression: A Double-Blind Randomized Clinical Trial.International journal of preventive medicine · 2023Article
- Effect of 0.02% and 0.01% atropine on ocular biometrics: A two-year clinical trial.Frontiers in pediatrics · 2023Article
- Electroretinogram responses in myopia: a review.Documenta ophthalmologica. Advances in ophthalmology · 2022Review
- The Impact of Clinical Atropine Use in Taiwanese Schoolchildren: Changes in Physiological Characteristics and Visual Functions.Children (Basel, Switzerland) · 2021Article
- The acute effect of atropine eye drops on the human full-field electroretinogram.Documenta ophthalmologica. Advances in ophthalmology · 2021Article
- The Effect of Low-Dose Atropine on Alpha Ganglion Cell Signaling in the Mouse Retina.Frontiers in cellular neuroscience · 2021Article
- Comments on: Changes in pattern electroretinogram after application of 0.01% atropine eye drops.Indian journal of ophthalmology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo assess retinal function by multifocal electroretinogram (mfERG) in children on atropine eye drops for the treatment of myopia.
methodsmfERGs were recorded in children receiving atropine eye drops (n = 48) once daily for 2 years and in those receiving placebo eye drops (n = 57) for a similar time. All recordings were performed between the second and third month of cessation of atropine/placebo treatment by a masked investigator. The amplitude and implicit time of the first order kernel (k1) and first slice of the second order kernel (k21) of mfERG responses were used to study the outer and inner retinal function, respectively.
resultsThere was no significant reduction in k1 response amplitudes of the atropine group compared to that of the placebo group (N1, p = 0.181; P1, p = 0.150). No significant difference in the k1 response implicit times between the groups was found (N1, p = 0.767; P1, p = 0.849). The differences in the k21 amplitudes and implicit times between the groups were not statistically significant (k21 amplitude, p = 0.058; k21 implicit time, p = 0.156).
conclusionsDaily atropine usage over 2 years for the treatment of myopia has no significant effect on retinal function as demonstrated by recordings of mfERG.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.