ArticleProceedings of the National Academy of Sciences of the United States of America2005
Ancestry and progeny of nutrient amino acid transporters.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 61 citations in OpenAlex.
- The Lepidopteran KAAT1 and CAATCH1: Orthologs to Understand Structure-Function Relationships in Mammalian SLC6 Transporters.Neurochemical research · 2022Article
- Article
- A SLC6 transporter cloned from the lion's mane jellyfish (Cnidaria, Scyphozoa) is expressed in neurons.PloS one · 2019Article
- Genome-Wide Identification, Characterization and Expression Analysis of the Solute Carrier 6 Gene Family in Silkworm (Bombyx mori).International journal of molecular sciences · 2016Article
- The D-amino acid transport by the invertebrate SLC6 transporters KAAT1 and CAATCH1 from Manduca sexta.Physiological reports · 2016Article
- Knockdown of a nutrient amino acid transporter gene LdNAT1 reduces free neutral amino acid contents and impairs Leptinotarsa decemlineata pupation.Scientific reports · 2015Article
- Drosophila melanogaster as a genetic model system to study neurotransmitter transporters.Neurochemistry international · 2014Review
- A novel eukaryotic Na+ methionine selective symporter is essential for mosquito development.Insect biochemistry and molecular biology · 2013Article
- An SLC6 transporter of the novel B(0,)- system aids in absorption and detection of nutrient amino acids in Caenorhabditis elegans.The Journal of experimental biology · 2013Article
- An inverse relationship links temperature and substrate apparent affinity in the ion-coupled cotransporters rGAT1 and KAAT1.International journal of molecular sciences · 2012Article
- Nerveless and gutsy: intestinal nutrient sensing from invertebrates to humans.Seminars in cell & developmental biology · 2012Review
- Molecular basis of essential amino acid transport from studies of insect nutrient amino acid transporters of the SLC6 family (NAT-SLC6).Journal of insect physiology · 2012Review
- SLC7 amino acid transporters of the yellow fever mosquito Aedes aegypti and their role in fat body TOR signaling and reproduction.Journal of insect physiology · 2012Article
- Novel male-biased expression in paralogs of the aphid slimfast nutrient amino acid transporter expansion.BMC evolutionary biology · 2011Article
- AaCAT1 of the yellow fever mosquito, Aedes aegypti: a novel histidine-specific amino acid transporter from the SLC7 family.The Journal of biological chemistry · 2011Article
- Neurotransmitter Transporter-Like: a male germline-specific SLC6 transporter required for Drosophila spermiogenesis.PloS one · 2011Article
- Transit through the flea vector induces a pretransmission innate immunity resistance phenotype in Yersinia pestis.PLoS pathogens · 2010Article
- Cellular mechanisms of acid secretion in the posterior midgut of the larval mosquito (Aedes aegypti).The Journal of experimental biology · 2010Article
- A putative amino acid transporter of the solute carrier 6 family is upregulated by lithium and is required for resistance to lithium toxicity in Drosophila.Neuroscience · 2009Article
- Characterization of a blood-meal-responsive proton-dependent amino acid transporter in the disease vector, Aedes aegypti.The Journal of experimental biology · 2009Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The biosynthesis of structural and signaling molecules depends on intracellular concentrations of essential amino acids, which are maintained by a specific system of plasma membrane transporters. We identify a unique population of nutrient amino acid transporters (NATs) within the sodium-neurotransmitter symporter family and have characterized a member of the NAT subfamily from the larval midgut of the Yellow Fever vector mosquito, Aedes aegypti (aeAAT1, AAR08269), which primarily supplies phenylalanine, an essential substrate for the synthesis of neuronal and cuticular catecholamines. Further analysis suggests that NATs constitute a comprehensive transport metabolon for the epithelial uptake and redistribution of essential amino acids including precursors of several neurotransmitters. In contrast to the highly conserved subfamily of orthologous neurotransmitter transporters, lineage-specific, paralogous NATs undergo rapid gene multiplication/substitution that enables a high degree of evolutionary plasticity of nutrient amino acid uptake mechanisms and facilitates environmental and nutrient adaptations of organisms. These findings provide a unique model for understanding the molecular mechanisms, physiology, and evolution of amino acid and neurotransmitter transport systems and imply that monoamine and GABA transporters evolved by selection and conservation of earlier neuronal NATs.
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