ArticleInfection and immunity2005
Down-regulation of the kps region 1 capsular assembly operon following attachment of Escherichia coli type 1 fimbriae to D-mannose receptors.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Escherichia coli Aggregates Mediated by Native or Synthetic Adhesins Exhibit Both Core and Adhesin-Specific Transcriptional Responses.Microbiology spectrum · 2023Article
- Extraintestinal PathogenicPathogens (Basel, Switzerland) · 2021Review
- Functional Insights From KpfR, a New Transcriptional Regulator of Fimbrial Expression That Is Crucial forFrontiers in microbiology · 2020Article
- Virulence factors, prevalence and potential transmission of extraintestinal pathogenicGut pathogens · 2019Review
- Differential Regulation ofJournal of pathogens · 2018Article
- Dynamics and genetic diversification ofPeerJ · 2017Article
- Fimbrial phase variation: stochastic or cooperative?Current genetics · 2016Review
- Perspective: Adhesion Mediated Signal Transduction in Bacterial Pathogens.Pathogens (Basel, Switzerland) · 2016Review
- Community signalling between Streptococcus gordonii and Porphyromonas gingivalis is controlled by the transcriptional regulator CdhR.Molecular microbiology · 2010Article
- Transcriptional response of E. coli upon FimH-mediated fimbrial adhesion.Gene regulation and systems biology · 2010Article
- Urothelial cultures support intracellular bacterial community formation by uropathogenic Escherichia coli.Infection and immunity · 2009Article
- Characterization of Klebsiella pneumoniae type 1 fimbriae by detection of phase variation during colonization and infection and impact on virulence.Infection and immunity · 2008Article
- Complicated catheter-associated urinary tract infections due to Escherichia coli and Proteus mirabilis.Clinical microbiology reviews · 2008Review
- Broad-spectrum biofilm inhibition by a secreted bacterial polysaccharide.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- A complex transcription network controls the early stages of biofilm development by Escherichia coli.Journal of bacteriology · 2006Review
- Capsule and fimbria interaction in Klebsiella pneumoniae.Infection and immunity · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
A differential-display PCR procedure identified the capsular assembly gene kpsD after Escherichia coli type 1 fimbrial binding to mannose-coated Sepharose beads. Limiting-dilution reverse-transcribed PCRs confirmed down-regulation of the kpsD gene, and Northern blot and lacZ fusion analyses showed down-regulation of the kpsFEDUCS region 1 operon. KpsD protein levels fell, and an agglutination test showed less K capsular antigen on the surface following the bacterial ligand-receptor interaction. These data show that binding of type 1 fimbriae (pili) to d-mannose receptors triggers a cross talk that leads to down-regulation of the capsule assembly region 1 operon in uropathogenic E. coli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.