Evidence map›Paper›PMID 15664962›Full record

ArticleInfection and immunity2005

Defective phagocytosis in Anaplasma phagocytophilum-infected neutrophils.

Justin W A Garyu, Kyoung-seong Choi, Dennis J Grab, J Stephen Dumler

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Innate immunity in rickettsial infections.Frontiers in cellular and infection microbiology · 2023
    Review
  3. Journal of feline medicine and surgery · 2020
    Review
  4. Frontiers in public health · 2020
    Article
  5. Article
  6. Alternative Splicing of Differentiated Myeloid Cell Transcripts after Infection byFrontiers in cellular and infection microbiology · 2018
    Article
  7. Genome-WideFrontiers in cellular and infection microbiology · 2016
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Immunodeficiencies caused by infectious diseases.The Veterinary clinics of North America. Small animal practice · 2010
    Review
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Justin W A GaryuDepartment of Pathology, Division of Medical Microbiology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 624, Baltimore, MD 21205, USA.
Kyoung-seong Choi
Dennis J Grab
J Stephen Dumler
Johns Hopkins Medicine · US

Funding

EHRLICHIA-GRANULOCYTE INTERACTIONS AND INFECTIONR01AI044102 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI DUMLER, JOHN STEPHEN · 2000 to 2019
$5.3M
NIAID NIH HHS R01 AI044102NIAID NIH HHS R01 AI 44102
6 · The paper itself

Abstract

Anaplasma phagocytophilum infection induces functional neutrophil changes. Using both Candida albicans and fluorescent-aggregate phagocytosis assays, we examined whether neutrophil and dimethyl sulfoxide-differentiated HL-60 cell infection impairs internalization. A. phagocytophilum infection significantly decreased phagocytosis compared to that of controls (P < 0.05). This further impairment of neutrophil function may promote opportunistic infections and exacerbate disease.

Indexed as

Anaplasma phagocytophilumCandida albicansHumansNeutrophilsPhagocytosis

Identifiers

PMID15664962
PMCPMC547103
OpenAlexW2143192788

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.