ArticleInfection and immunity2005
Role of contact lens wear, bacterial flora, and mannose-induced pathogenic protease in the pathogenesis of amoebic keratitis.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.
- Medical interventions for acanthamoeba keratitis.The Cochrane database of systematic reviews · 2015Pooled it
- Prevalence of HSV Genomic Signatures Among Acanthamoeba Hosts and Contaminated Lens Cases: A Molecular and Clinical Study.Investigative ophthalmology & visual science · 2025Article
- Concomitant Potentially Contagious Factors Detected in Poland and RegardingMicroorganisms · 2024Article
- Development of an Ex Vivo Porcine Eye Model for Exploring the Pathogenicity ofMicroorganisms · 2024Article
- Understanding Acanthamoeba Keratitis: An In-Depth Review of a Sight-Threatening Eye Infection.Microorganisms · 2024Review
- Experimental Induction of Acute Acanthamoeba castellanii Keratitis in Cats.Translational vision science & technology · 2023Article
- Effectiveness of Polyclonal Antibody Immunoconjugate Treatment with Propamidine Isethionate for Amoebic Keratitis in Golden Hamsters.Journal of parasitology research · 2023Article
- Free-Living Amoeba Vermamoeba vermiformis Induces Allergic Airway Inflammation.The Korean journal of parasitology · 2022Article
- Interaction between Naegleria fowleri and pathogenic Escherichia coli by mannose and changes in N. fowleri protease.Parasitology research · 2022Article
- The biology of Acanthamoeba keratitis.Experimental eye research · 2021Review
- Extracellular protease profile of Acanthamoeba after prolonged axenic culture and after interaction with MDCK cells.Parasitology research · 2020Article
- Associated factors, diagnosis and management of Acanthamoeba keratitis in a referral Center in Southern China.BMC ophthalmology · 2017Article
- Pathobiology and Immunobiology ofThe Yale journal of biology and medicine · 2017Review
- Contact lens associated microbial keratitis: practical considerations for the optometrist.Clinical optometry · 2016Review
- Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells.Investigative ophthalmology & visual science · 2014Article
- Role of phospholipase A₂ (PLA₂) inhibitors in attenuating apoptosis of the corneal epithelial cells and mitigation of Acanthamoeba keratitis.Experimental eye research · 2013Article
- Proteases from Entamoeba spp. and Pathogenic Free-Living Amoebae as Virulence Factors.Journal of tropical medicine · 2013Article
- Acanthamoeba-cytopathic protein induces apoptosis and proinflammatory cytokines in human corneal epithelial cells by cPLA2α activation.Investigative ophthalmology & visual science · 2012Article
- NKT cells are necessary for maximal expression of allergic conjunctivitis.International immunology · 2010Article
- Pathogenesis of acanthamoeba keratitis.The ocular surface · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The ocular surface is continuously exposed to potential pathogens, including free-living amoebae. Acanthamoeba species are among the most ubiquitous amoebae, yet Acanthamoeba keratitis is remarkably rare. The pathogenesis of Acanthamoeba keratitis is a complex, sequential process. Here we show that Acanthamoeba keratitis is profoundly affected by mannosylated proteins on the ocular surface, which stimulate the amoebae to elaborate a 133-kDa pathogenic protease. The mannose-induced protease (MIP133) mediates apoptosis of the corneal epithelium, facilitates corneal invasion, and degrades the corneal stroma. We show that contact lens wear upregulates mannosylated proteins on the corneal epithelium, stimulates MIP133 secretion, and exacerbates corneal disease. Corynebacterium xerosis, a constituent of the ocular flora, contains large amounts of mannose and is associated with Acanthamoeba keratitis. The present results show that amoebae exposed to C. xerosis produce increased amounts of MIP133 and more severe corneal disease. Oral immunization with MIP133 mitigates Acanthamoeba keratitis and demonstrates the feasibility of antidisease vaccines for pathogens that resist immune elimination.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.