ArticleInfection and immunity2005
Staphylococcus aureus virulence factors identified by using a high-throughput Caenorhabditis elegans-killing model.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Article
- Combined transcriptome and whole genome sequencing analyses reveal candidate drug-resistance genes ofiScience · 2025Article
- Identification of a staphylococcal dipeptidase involved in the production of human body odor.The Journal of biological chemistry · 2024Article
- Identification of the Genes of the Plant PathogenFrontiers in microbiology · 2022Article
- Silkworm model forVirulence · 2021Article
- Microbial 5'-nucleotidases: their characteristics, roles in cellular metabolism, and possible practical applications.Applied microbiology and biotechnology · 2021Review
- Article
- Fisetin LowersFrontiers in microbiology · 2018Article
- High-Throughput Genetic Screen Reveals that Early Attachment and Biofilm Formation Are Necessary for Full Pyoverdine Production byFrontiers in microbiology · 2017Article
- Animals devoid of pulmonary system as infection models in the study of lung bacterial pathogens.Frontiers in microbiology · 2015Review
- Repurposing salicylanilide anthelmintic drugs to combat drug resistant Staphylococcus aureus.PloS one · 2015Article
- Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes.Immunity · 2014Article
- Discovery of potential anti-infectives against Staphylococcus aureus using a Caenorhabditis elegans infection model.BMC complementary and alternative medicine · 2014Article
- Whole animal automated platform for drug discovery against multi-drug resistant Staphylococcus aureus.PloS one · 2014Article
- Catabolite control protein E (CcpE) is a LysR-type transcriptional regulator of tricarboxylic acid cycle activity in Staphylococcus aureus.The Journal of biological chemistry · 2013Article
- Staphylococcus saprophyticus surface-associated protein (Ssp) is associated with lifespan reduction in Caenorhabditis elegans.Virulence · 2013Article
- Effect of oxygen on glucose metabolism: utilization of lactate in Staphylococcus aureus as revealed by in vivo NMR studies.PloS one · 2013Article
- Article
- Type I signal peptidase and protein secretion in Staphylococcus aureus.Journal of bacteriology · 2012Article
- Expression of multidrug resistance efflux pump gene norA is iron responsive in Staphylococcus aureus.Journal of bacteriology · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Staphylococcus aureus is an important human pathogen that is also able to kill the model nematode Caenorhabditis elegans. We constructed a 2,950-member Tn917 transposon insertion library in S. aureus strain NCTC 8325. Twenty-one of these insertions exhibited attenuated C. elegans killing, and of these, 12 contained insertions in different genes or chromosomal locations. Ten of these 12 insertions showed attenuated killing phenotypes when transduced into two different S. aureus strains, and 5 of the 10 mutants correspond to genes that have not been previously identified in signature-tagged mutagenesis studies. These latter five mutants were tested in a murine renal abscess model, and one mutant harboring an insertion in nagD exhibited attenuated virulence. Interestingly, Tn917 was shown to have a very strong bias for insertions near the terminus of DNA replication.
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