ArticleNeuroscience2005
The role of mPer1 in morphine dependence in mice.
Article in Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 54 citations in OpenAlex.
- Disrupted circadian rhythms and opioid-mediated adverse effects: Bidirectional relationship and putative mechanisms.Journal of neuroendocrinology · 2025Review
- The disruptive relationship among circadian rhythms, pain, and opioids.Frontiers in neuroscience · 2023Review
- Molecular Mechanism of Neuroprotective Effect of Melatonin on Morphine Addiction and Analgesic Tolerance: an Update.Molecular neurobiology · 2021Review
- Review
- mPer1 promotes morphine-induced locomotor sensitization and conditioned place preference via histone deacetylase activity.Psychopharmacology · 2017Article
- Review
- Exploring the role of locomotor sensitization in the circadian food entrainment pathway.PloS one · 2017Article
- Circadian clock genes: effects on dopamine, reward and addiction.Alcohol (Fayetteville, N.Y.) · 2015Review
- Direct regulation of diurnal Drd3 expression and cocaine reward by NPAS2.Biological psychiatry · 2015Article
- Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour.Nature communications · 2014Article
- Circadian rhythms and addiction: mechanistic insights and future directions.Behavioral neuroscience · 2014Review
- The role of clock in ethanol-related behaviors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- Advances in genetic studies of substance abuse in China.Shanghai archives of psychiatry · 2013Review
- Differential regulation of the period genes in striatal regions following cocaine exposure.PloS one · 2013Article
- Persistent gene expression changes in ventral tegmental area of adolescent but not adult rats in response to chronic nicotine.Neuroscience · 2010Article
- A role for the circadian genes in drug addiction.Neuropharmacology · 2009Review
- Genetic susceptibility to heroin addiction: a candidate gene association study.Genes, brain, and behavior · 2008Article
- Brothers in arms: DNA enzymes, short interfering RNA, and the emerging wave of small-molecule nucleic acid-based gene-silencing strategies.The American journal of pathology · 2007Review
- Clock genes running amok. Clock genes and their role in drug addiction and depression.EMBO reports · 2007Review
- Altered expression of circadian clock gene, mPer1, in mouse brain and kidney under morphine dependence and withdrawal.Journal of circadian rhythms · 2006Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Investigations using Drosophila melanogaster have shown that the circadian clock gene period can influence behavioral responses to cocaine, and the mouse homologues, mPer1 and mPer2, modulate cocaine sensitization and reward. In the present study, we applied DNAzyme targeting mPer1 to interfere the expression of mPer1 in CNS in mice and studied the role of mPer1 on morphine dependence. We found that the DNAzyme could attenuate the expression of mPer1 in CNS in mice. Mice treated with DNAzyme and morphine synchronously did not show preference to the morphine-trained side, whereas the control group did. In contrast, mice treated with DNAzyme after morphine showed preference to the morphine-trained side as well as the control group did. These results indicate that drug dependence seems to be influenced at least partially by mPer1, but mPer1 cannot affect morphine dependence that has been formed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.