ArticleMolecular and cellular biochemistry2004
Calcium-modulated ciliary membrane guanylate cyclase transduction machinery: constitution and operational principles.
Article in Molecular and cellular biochemistry, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Multilimbed membrane guanylate cyclase signaling system, evolutionary ladder.Frontiers in molecular neuroscience · 2022Review
- CaFrontiers in molecular neuroscience · 2018Article
- Integrative Signaling Networks of Membrane Guanylate Cyclases: Biochemistry and Physiology.Frontiers in molecular neuroscience · 2016Review
- Membrane guanylate cyclase, a multimodal transduction machine: history, present, and future directions.Frontiers in molecular neuroscience · 2014Review
- Ca(2+)-modulated ROS-GC1 transduction system in testes and its presence in the spermatogenic cells.Frontiers in molecular neuroscience · 2014Article
- Atrial natriuretic factor receptor guanylate cyclase, ANF-RGC, transduces two independent signals, ANF and Ca(2+).Frontiers in molecular neuroscience · 2014Review
- Ca(2+) modulation of ANF-RGC: new signaling paradigm interlocked with blood pressure regulation.Biochemistry · 2012Article
- Ca(2+)-sensors and ROS-GC: interlocked sensory transduction elements: a review.Frontiers in molecular neuroscience · 2012Article
- Antithetical modes of and the Ca(2+) sensors targeting in ANF-RGC and ROS-GC1 membrane guanylate cyclases.Frontiers in molecular neuroscience · 2012Article
- Expression of calcium binding proteins in mouse type II taste cells.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2011Article
- Ca(2+) sensor GCAP1: A constitutive element of the ONE-GC-modulated odorant signal transduction pathway.Biochemistry · 2010Article
- Distinct ONE-GC transduction modes and motifs of the odorants: Uroguanylin and CO(2).Biochemical and biophysical research communications · 2010Article
- Odorant-linked ROS-GC subfamily membrane guanylate cyclase transduction system.Molecular and cellular biochemistry · 2010Review
- Membrane guanylate cyclase is a beautiful signal transduction machine: overview.Molecular and cellular biochemistry · 2010Review
- ROS-GC subfamily membrane guanylate cyclase-linked transduction systems: taste, pineal gland and hippocampus.Molecular and cellular biochemistry · 2010Review
- Receptor guanylyl cyclases in mammalian olfactory function.Molecular and cellular biochemistry · 2010Review
- Olfactory receptors: G protein-coupled receptors and beyond.Journal of neurochemistry · 2009Review
- Hippocalcin, new Ca(2+) sensor of a ROS-GC subfamily member, ONE-GC, membrane guanylate cyclase transduction system.Molecular and cellular biochemistry · 2009Article
- Visinin-like proteins (VSNLs): interaction partners and emerging functions in signal transduction of a subfamily of neuronal Ca2+ -sensor proteins.Cell and tissue research · 2009Review
- Neurocalcin delta modulation of ROS-GC1, a new model of Ca(2+) signaling.Biochemistry · 2008Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Odorant transduction is a biochemical process by which the odorant signal generates the electric signal. The cilia of the olfactory neuroepithelium are the sites of this process. This study documents the detailed biochemical, structural and functional description of an odorant-responsive Ca2+ -modulated membrane guanylate cyclase transduction machinery in the cilia. Myristoylated (myr)-neurocalcin delta is the Ca2+ -sensor component and the cyclase, ONE-GC, the transduction component of the machinery. Myr-neurocalcin delta senses increments in free Ca2+, binds to a defined domain of ONE-GC and stimulates the cyclase. The findings enable the formulation of an odorant transduction model in which three pivotal signaling components--Ca2+, myr-neurocalcin delta and ONE-GC--of the transduction machinery are locked. A glaring feature of the model is that its Ca2+ -dependent operational principle is opposite to the phototransduction model.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.