ArticleVeterinary immunology and immunopathology2005
Canine distemper virus-induced depletion of uninfected lymphocytes is associated with apoptosis.
Article in Veterinary immunology and immunopathology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 76 citations in OpenAlex.
- Genetic characterization and structural insights of canine astroviruses circulating in South Korea.BMC veterinary research · 2026Article
- Immunohistochemical investigation of canine lymph nodes collected during a rabies outbreak in South Africa.The Journal of general virology · 2025Article
- Hematological Changes and Immunomodulation of Neutrophil and Monocyte Populations in Shelter Dogs.Animals : an open access journal from MDPI · 2025Article
- Phenotypic Characterization of Encephalitis in the BRAINS of Badgers Naturally Infected with Canine Distemper Virus.Animals : an open access journal from MDPI · 2023Article
- Phenotypic and Transcriptional Changes of Pulmonary Immune Responses in Dogs Following Canine Distemper Virus Infection.International journal of molecular sciences · 2022Article
- Review
- Indicators of the molecular pathogenesis of virulent Newcastle disease virus in chickens revealed by transcriptomic profiling of spleen.Scientific reports · 2021Article
- Combining vanadyl sulfate with Newcastle disease virus potentiates rapid innate immune-mediated regression with curative potential in murine cancer models.Molecular therapy oncolytics · 2021Article
- Tropism and molecular pathogenesis of canine distemper virus.Virology journal · 2019Review
- Comparative Immunopathology ofFrontiers in immunology · 2019Article
- Oncolytic Viruses for Canine Cancer Treatment.Cancers · 2018Review
- Expression of canine distemper virus receptor nectin-4 in the central nervous system of dogs.Scientific reports · 2017Article
- Morbillivirus Experimental Animal Models: Measles Virus Pathogenesis Insights from Canine Distemper Virus.Viruses · 2016Review
- Cross-species transmission of canine distemper virus-an update.One health (Amsterdam, Netherlands) · 2015Review
- Membrane fusion-mediated autophagy induction enhances morbillivirus cell-to-cell spread.Journal of virology · 2012Article
- Immunopathogenic and neurological mechanisms of canine distemper virus.Advances in virology · 2012Article
- Immunodeficiencies caused by infectious diseases.The Veterinary clinics of North America. Small animal practice · 2010Review
- Canine distemper virus selectively inhibits apoptosis progression in infected immune cells.Journal of virology · 2009Article
- Ferrets as a model for morbillivirus pathogenesis, complications, and vaccines.Current topics in microbiology and immunology · 2009Review
- Development of a challenge-protective vaccine concept by modification of the viral RNA-dependent RNA polymerase of canine distemper virus.Journal of virology · 2007Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Canine distemper virus (CDV), a negative stranded RNA morbillivirus, causes a multisystemic disease in dogs, which is associated with a severe immune suppression. The aim of the study was to examine the influence of early CDV infection on leukocyte depletion, lymphopenia and virus-induced cell death in dogs infected with a virulent CDV strain. From 10 infected dogs, peripheral blood leukocytes were harvested periodically, phenotyped and analyzed for CDV antigen content and apoptosis using Annexin V-FITC and propidium iodide labeling. CDV infection induced a severe CD3+ T cell and CD21+ B cell depletion in all animals at 3 days post-infection (d.p.i.). For dogs with severe distemper, developing virus persistence in the lymphoid tissue and central nervous system, this lymphopenia lasted until the end of the experiment. Increased levels of lymphocyte apoptosis were found at 3 d.p.i., and monocyte apoptosis at 6 d.p.i. This was more prominent in the group of animals with severe distemper. At 3 d.p.i. no leukocyte infection was detectable indicating that the early lymphocyte depletion and apoptosis was not a direct consequence of virus infection. Taken together, our results demonstrate that CDV-induced lymphopenia is an early event and that the degree of lymphocyte depletion correlates with the severity of disease and virus persistence in the lymphoid tissue and central nervous system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.