ArticlePflugers Archiv : European journal of physiology2005
Regulation of the voltage-gated potassium channel KCNQ4 in the auditory pathway.
Article in Pflugers Archiv : European journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 46 citations in OpenAlex.
- Modulation of BK-like potassium currents by ketamine in rat cochlear outer hair cells.Molecular brain · 2026Article
- Prestin amplifies cardiac motor functions.Cell reports · 2021Article
- Cooperativity of KScience advances · 2020Article
- Activation of KBritish journal of pharmacology · 2019Article
- Phosphatidylinositol 4,5-bisphosphate (PIPThe Journal of biological chemistry · 2018Article
- βBritish journal of pharmacology · 2018Article
- Chansporter complexes in cell signaling.FEBS letters · 2017Review
- Muscarinic Acetylcholine Receptors and M-Currents Underlie Efferent-Mediated Slow Excitation in Calyx-Bearing Vestibular Afferents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Kv7 Channel Activation Underpins EPAC-Dependent Relaxations of Rat Arteries.Arteriosclerosis, thrombosis, and vascular biology · 2016Article
- Kv7.5 Potassium Channel Subunits Are the Primary Targets for PKA-Dependent Enhancement of Vascular Smooth Muscle Kv7 Currents.Molecular pharmacology · 2016Article
- A method to control phosphoinositides and to analyze PTEN function in living cells using voltage sensitive phosphatases.Frontiers in pharmacology · 2015Article
- The M-current contributes to high threshold membrane potential oscillations in a cell type-specific way in the pedunculopontine nucleus of mice.Frontiers in cellular neuroscience · 2015Article
- Article
- Adenylate cyclase 1 (ADCY1) mutations cause recessive hearing impairment in humans and defects in hair cell function and hearing in zebrafish.Human molecular genetics · 2014Article
- Mechanotransduction and hyperpolarization-activated currents contribute to spontaneous activity in mouse vestibular ganglion neurons.The Journal of general physiology · 2014Article
- Effects of KCNQ channel modulators on the M-type potassium current in primate retinal pigment epithelium.American journal of physiology. Cell physiology · 2012Article
- Extracellular chloride regulation of Kv2.1, contributor to the major outward Kv current in mammalian outer hair cells.American journal of physiology. Cell physiology · 2012Article
- KCNQ5 channels control resting properties and release probability of a synapse.Nature neuroscience · 2011Article
- Effect of capsaicin on potassium conductance and electromotility of the guinea pig outer hair cell.Hearing research · 2011Article
- Vascular KCNQ channels in humans: the sub-threshold brake that regulates vascular tone?British journal of pharmacology · 2011Article
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2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The potassium channel KCNQ4, expressed in the mammalian cochlea, has been associated tentatively with an outer hair cell (OHC) potassium current, I(K,n), a current distinguished by an activation curve shifted to exceptionally negative potentials. Using CHO cells as a mammalian expression system, we have examined the properties of KCNQ4 channels under different phosphorylation conditions. The expressed current showed the typical KCNQ4 voltage-dependence, with a voltage for half-maximal activation (V(1/2)) of -25 mV, and was blocked almost completely by 200 microM linopirdine. Application of 8-bromo-cAMP or the catalytic sub-unit of PKA shifted V(1/2) by approximately -10 and -20 mV, respectively. Co-expression of KCNQ4 and prestin, the OHC motor protein, altered the voltage activation by a further -15 mV. Currents recorded with less than 1 nM Ca(2+) in the pipette ran down slowly (12% over 5 min). Buffering the pipette Ca(2+) to 100 nM increased the run-down rate sevenfold. Exogenous PKA in the pipette prevented the effect of elevated [Ca(2+)](i) on run-down. Inhibition of the calcium binding proteins calmodulin or calcineurin by W-7 or cyclosporin A, respectively, also prevented the calcium-dependent rapid run-down. We suggest that KCNQ4 phosphorylation via PKA and coupling to a complex that may include prestin can lead to the negative activation and the negative resting potential found in adult OHCs.
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