ArticleJournal of bacteriology2005
Isolation and characterization of an aldehyde dehydrogenase encoded by the aldB gene of Escherichia coli.
Article in Journal of bacteriology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 76 citations in OpenAlex.
- Nutrient control enables metabolic reconstruction ofbioRxiv : the preprint server for biology · 2026Article
- Bacterial metabolic signatures in MASLD predicted through gene-centric studies in stool metagenomes.BMC microbiology · 2025Article
- Taxonomic distribution of alkane synthesizing aldehyde dehydrogenases across bacteria, fungi, plants, and animals.Biotechnology for biofuels and bioproducts · 2025Article
- Contribution of a C-Terminal Extension to the Substrate Affinity and Oligomeric Stability of Aldehyde Dehydrogenase fromBiochemistry · 2024Article
- Structure Prediction and Characterization of Thermostable Aldehyde Dehydrogenase from Newly IsolatedMicroorganisms · 2022Article
- Zymomonas mobilis ZM4 Utilizes an NADPJournal of bacteriology · 2022Article
- Knowns and Unknowns of Vitamin BEcoSal Plus · 2021Review
- Overproduction of docosahexaenoic acid in Schizochytrium sp. through genetic engineering of oxidative stress defense pathways.Biotechnology for biofuels · 2021Article
- Optimized expression of Hfq protein increases Escherichia coli growth.Journal of biological engineering · 2021Article
- Insights into Aldehyde Dehydrogenase Enzymes: A Structural Perspective.Frontiers in molecular biosciences · 2021Review
- Expression of acetaldehyde dehydrogenase (aldB) improved ethanol production from xylose by the ethanologenic Escherichia coli RM10.World journal of microbiology & biotechnology · 2020Article
- Effect of ethanol supplementation on the transcriptional landscape of bionanocellulose producer Komagataeibacter xylinus E25.Applied microbiology and biotechnology · 2019Article
- Metabolic Engineering ofFrontiers in bioengineering and biotechnology · 2018Article
- Metabolic engineering of Escherichia coli to high efficient synthesis phenylacetic acid from phenylalanine.AMB Express · 2017Article
- Mechanistic insights into manganese oxidation of a soil-borne Mn(II)-oxidizing Escherichia coli strain by global proteomic and genetic analyses.Scientific reports · 2017Article
- Sugar Metabolism of the First Thermophilic PlanctomyceteFrontiers in microbiology · 2017Article
- An Efficient Site-Specific Method for Irreversible Covalent Labeling of Proteins with a Fluorophore.Scientific reports · 2015Article
- Primary Amine Oxidase of Escherichia coli Is a Metabolic Enzyme that Can Use a Human Leukocyte Molecule as a Substrate.PloS one · 2015Article
- Molecular characterization of a thermostable aldehyde dehydrogenase (ALDH) from the hyperthermophilic archaeon Sulfolobus tokodaii strain 7.Extremophiles : life under extreme conditions · 2013Article
- Group X aldehyde dehydrogenases of Pseudomonas aeruginosa PAO1 degrade hydrazones.Journal of bacteriology · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
An aldehyde dehydrogenase was detected in crude cell extracts of Escherichia coli DH5alpha. Growth studies indicated that the aldehyde dehydrogenase activity was growth phase dependent and increased in cells grown with ethanol. The N-terminal amino acid sequence of the purified enzyme identified the latter as an aldehyde dehydrogenase encoded by aldB, which was thought to play a role in the removal of aldehydes and alcohols in cells that were under stress. The purified enzyme showed an estimated molecular mass of 220 +/- 8 kDa, consisting of four identical subunits, and preferred to use NADP and acetaldehyde. MgCl2 increased the activity of the NADP-dependent enzyme with various substrates. A comparison of the effect of Mg2+ ions on the bacterial enzyme with the effect of Mg2+ ions on human liver mitochondrial aldehyde dehydrogenase revealed that the bacterial enzyme shared kinetic properties with the mammalian enzyme. An R197E mutant of the bacterial enzyme appeared to retain very little NADP-dependent activity on acetaldehyde.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.