ArticleThe Plant cell2005
DISTORTED3/SCAR2 is a putative arabidopsis WAVE complex subunit that activates the Arp2/3 complex and is required for epidermal morphogenesis.
Article in The Plant cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed, 125 citations in OpenAlex.
- Recent insights into the plant ARP2/3 complex.Protoplasma · 2026Review
- Cytoskeletal control of development and environmental adaptation in plants.Science China. Life sciences · 2026Review
- Functional divergence of plant SCAR/WAVE proteins is determined by intrinsically disordered regions.Science advances · 2025Article
- A Genome-Wide Association Screen for Genes Affecting Leaf Trichome Development and Epidermal Metal Accumulation in Arabidopsis.Plant, cell & environment · 2025Article
- A dual transcriptome analysis reveals accession-specific resistance responses inFrontiers in plant science · 2025Article
- CRISPR-Cas9 Arabidopsis mutants of genes for ARPC1 and ARPC3 subunits of ARP2/3 complex reveal differential roles of complex subunits.Scientific reports · 2022Article
- Cell biology of the leaf epidermis: Fate specification, morphogenesis, and coordination.The Plant cell · 2022Review
- Article
- Insights into the molecular evolution of fertilization mechanism in land plants.Plant reproduction · 2021Review
- The ARP2/3 complex, acting cooperatively with Class I formins, modulates penetration resistance in Arabidopsis against powdery mildew invasion.The Plant cell · 2021Article
- Spatial and temporal localization of SPIRRIG and WAVE/SCAR reveal roles for these proteins in actin-mediated root hair development.The Plant cell · 2021Article
- Formins control dynamics of F-actin in the central cell ofPlant signaling & behavior · 2021Article
- Genome-Wide SNP Markers for Genotypic and Phenotypic Differentiation of Melon (International journal of molecular sciences · 2021Article
- ARP2/3-independent WAVE/SCAR pathway and class XI myosin control sperm nuclear migration in flowering plants.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Developmental Modulation of Root Cell Wall Architecture Confers Resistance to an Oomycete Pathogen.Current biology : CB · 2020Article
- GmNAP1 is essential for trichome and leaf epidermal cell development in soybean.Plant molecular biology · 2020Article
- Regulation of stomatal development by stomatal lineage miRNAs.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Evolutionary Comparison of the Developmental/Physiological Phenotype and the Molecular Behavior of SPIRRIG BetweenFrontiers in plant science · 2020Article
- Division of Labor Between Two Actin Nucleators-the Formin FH1 and the ARP2/3 Complex-inFrontiers in plant science · 2020Article
- Spatiotemporal cytoskeleton organizations determine morphogenesis of multicellular trichomes in tomato.PLoS genetics · 2019Article
1 more citing papers are in PubMed but not listed here.
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9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In a plant cell, a subset of actin filaments function as a scaffold that positions the endomembrane system and acts as a substrate on which organelle motility occurs. Other actin filament arrays appear to be more dynamic and reorganize in response to growth signals and external cues. The distorted group of trichome morphology mutants provides powerful genetic tools to study the control of actin filament nucleation in the context of morphogenesis. In this article, we report that DISTORTED3 (DIS3) encodes a plant-specific SCAR/WAVE homolog. Null alleles of DIS3, like those of other Arabidopsis thaliana WAVE and Actin-Related Protein (ARP) 2/3 subunit genes, cause trichome distortion, defects in cell-cell adhesion, and reduced hypocotyl growth in etiolated seedlings. DIS3 efficiently activates the actin filament nucleation and branching activity of vertebrate Arp2/3 and functions within a WAVE-ARP2/3 pathway in vivo. DIS3 may assemble into a WAVE complex via a physical interaction with a highly diverged Arabidopsis Abi-1-like bridging protein. These results demonstrate the utility of the Arabidopsis trichome system to understand how the WAVE and ARP2/3 complexes translate signaling inputs into a coordinated morphogenetic response.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.