ArticleThe Plant cell2005
Phosphoserines on maize CENTROMERIC HISTONE H3 and histone H3 demarcate the centromere and pericentromere during chromosome segregation.
Article in The Plant cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Thyme Oil Alleviates Cadmium-Induced Disturbances in Mitotic Activity, Cytoskeletal Organization and H3T3/H3S10 Phosphorylation inInternational journal of molecular sciences · 2026Article
- Perspectives of Genome Editing Mediated Haploid Inducer Systems in Legumes.International journal of molecular sciences · 2025Review
- The Genomics of Plant Satellite DNA.Progress in molecular and subcellular biology · 2021Review
- Comparing DNA replication programs reveals large timing shifts at centromeres of endocycling cells in maize roots.PLoS genetics · 2020Article
- Conservation of centromeric histone 3 interaction partners in plants.Journal of experimental botany · 2020Article
- Epigenetic regulation of centromere function.Cellular and molecular life sciences : CMLS · 2020Review
- Deregulated Phosphorylation of CENH3 at Ser65 Affects the Development of Floral Meristems inFrontiers in plant science · 2019Article
- Immunofluorescence Analysis of Endogenous and Exogenous Centromere-kinetochore Proteins.Journal of visualized experiments : JoVE · 2016Article
- Epigenetic Histone Marks of Extended Meta-Polycentric Centromeres of Lathyrus and Pisum Chromosomes.Frontiers in plant science · 2016Article
- Article
- Review
- Meiosis, unreduced gametes, and parthenogenesis: implications for engineering clonal seed formation in crops.Plant reproduction · 2015Review
- CENP-A K124 Ubiquitylation Is Required for CENP-A Deposition at the Centromere.Developmental cell · 2015Article
- Analysis of Histones H3 and H4 Reveals Novel and Conserved Post-Translational Modifications in Sugarcane.PloS one · 2015Article
- Immunolocalization of chromosome-associated proteins in plants - principles and applications.Botanical studies · 2014Review
- Ultrastructural changes associated with the induction of premature chromosome condensation in Vicia faba root meristem cells.Plant cell reports · 2014Article
- Looking at plant cell cycle from the chromatin window.Frontiers in plant science · 2014Review
- Microcystin-LR and cylindrospermopsin induced alterations in chromatin organization of plant cells.Marine drugs · 2013Review
- Phosphorylation of centromeric histone H3 variant regulates chromosome segregation in Saccharomyces cerevisiae.Molecular biology of the cell · 2013Article
- Distribution pattern of histone H3 phosphorylation at serine 10 during mitosis and meiosis in Brachiaria species.Journal of genetics · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have identified and characterized a 17- to 18-kD Ser50-phosphorylated form of maize (Zea mays) CENTROMERIC HISTONE H3 (phCENH3-Ser50). Immunostaining in both mitosis and meiosis indicates that CENH3-Ser50 phosphorylation begins in prophase/diplotene, increases to a maximum at prometaphase-metaphase, and drops during anaphase. Dephosphorylation is precipitous (approximately sixfold) at the metaphase-anaphase transition, suggesting a role in the spindle checkpoint. Although phCENH3-Ser50 lies within a region that lacks homology to any other known histone, its closest counterpart is the phospho-Ser28 residue of histone H3 (phH3-Ser28). CENH3-Ser50 and H3-Ser28 are phosphorylated with nearly identical kinetics, but the former is restricted to centromeres and the latter to pericentromeres. Opposing centromeres separate in prometaphase, whereas the phH3-Ser28-marked pericentromeres remain attached and coalesce into a well-defined tether that binds the centromeres together. We propose that a centromere-initiated wave of histone phosphorylation is an early step in defining the two major structural domains required for chromosome segregation: centromere (alignment, motility) and pericentromere (cohesion).
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