ArticleProceedings of the National Academy of Sciences of the United States of America2005
The trans-Golgi network-associated human ubiquitin-protein ligase POSH is essential for HIV type 1 production.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 83 citations in OpenAlex.
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- Comparison of anadromous and landlocked Atlantic salmon genomes reveals signatures of parallel and relaxed selection across the Northern Hemisphere.Evolutionary applications · 2021Article
- SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation.Nature communications · 2020Article
- Ubiquitination and SUMOylation in HIV Infection: Friends and Foes.Current issues in molecular biology · 2020Review
- Post-translational Modification-Based Regulation of HIV Replication.Frontiers in microbiology · 2018Review
- Proteasomal Degradation Machinery: Favorite Target of HIV-1 Proteins.Frontiers in microbiology · 2018Review
- Inhibitors of Deubiquitinating Enzymes Block HIV-1 Replication and Augment the Presentation of Gag-Derived MHC-I Epitopes.Viruses · 2017Article
- A Truncated Nef Peptide from SIVcpz Inhibits the Production of HIV-1 Infectious Progeny.Viruses · 2016Article
- HIV-1 Vpr redirects host ubiquitination pathway.Journal of virology · 2014Article
- Human Ubc9 is involved in intracellular HIV-1 Env stability after trafficking out of the trans-Golgi network in a Gag dependent manner.PloS one · 2013Article
- HIV Assembly and Budding: Ca(2+) Signaling and Non-ESCRT Proteins Set the Stage.Molecular biology international · 2012Article
- Activation of the retroviral budding factor ALIX.Journal of virology · 2011Article
- Evidence of a role for soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) machinery in HIV-1 assembly and release.The Journal of biological chemistry · 2011Article
- Filamin A protein interacts with human immunodeficiency virus type 1 Gag protein and contributes to productive particle assembly.The Journal of biological chemistry · 2011Article
- New insights into HIV assembly and trafficking.Physiology (Bethesda, Md.) · 2011Review
- Article
- Macrophages and Cell-Cell Spread of HIV-1.Viruses · 2010Article
- POSH stimulates the ubiquitination and the clathrin-independent endocytosis of ROMK1 channels.The Journal of biological chemistry · 2009Article
- Human Ubc9 contributes to production of fully infectious human immunodeficiency virus type 1 virions.Journal of virology · 2009Article
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Authors and funding
25 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
HIV type 1 (HIV-1) was shown to assemble either at the plasma membrane or in the membrane of late endosomes. Now, we report an essential role for human ubiquitin ligase POSH (Plenty of SH3s; hPOSH), a trans-Golgi network-associated protein, in the targeting of HIV-1 to the plasma membrane. Small inhibitory RNA-mediated silencing of hPOSH ablates virus secretion and Gag plasma membrane localization. Reintroduction of native, but not a RING finger mutant, hPOSH restores virus release and Gag plasma membrane localization in hPOSH-depleted cells. Furthermore, expression of the RING finger mutant hPOSH inhibits virus release and induces accumulation of intracellular Gag in normal cells. Together, our results identify a previously undescribed step in HIV biogenesis and suggest a direct function for hPOSH-mediated ubiquitination in protein sorting at the trans-Golgi network. Consequently, hPOSH may be a useful host target for therapeutic intervention.
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