ReviewCurrent allergy and asthma reports2005
Helminth infections: protection from atopic disorders.
Review in Current allergy and asthma reports, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- Severely Asthmatic Horses Residing in a Mediterranean Climate Shed a Significantly Lower Number of Parasite Eggs Compared to Healthy Farm Mates.Animals : an open access journal from MDPI · 2023Article
- Why has epidemiology not (yet) succeeded in identifying the origin of the asthma epidemic?International journal of epidemiology · 2023Article
- Immunological Considerations forFrontiers in immunology · 2021Review
- Type two innate lymphoid cells: the Janus cells in health and disease.Immunological reviews · 2017Review
- Somatic extracts of Marshallagia marshalli downregulate the Th2 associated immune responses in ovalbumin-induced airway inflammation in BALB/c mice.Parasites & vectors · 2017Article
- Regulation of the host immune system by helminth parasites.The Journal of allergy and clinical immunology · 2016Review
- The Microbiota, Immunoregulation, and Mental Health: Implications for Public Health.Current environmental health reports · 2016Review
- Down Regulation of the TCR Complex CD3ζ-Chain on CD3+ T Cells: A Potential Mechanism for Helminth-Mediated Immune Modulation.Frontiers in immunology · 2015Article
- Early development of the gut microbiota and immune health.Pathogens (Basel, Switzerland) · 2014Review
- Human type 1 and 17 responses in latent tuberculosis are modulated by coincident filarial infection through cytotoxic T lymphocyte antigen-4 and programmed death-1.The Journal of infectious diseases · 2009Article
- Lower expression of TLR2 and SOCS-3 is associated with Schistosoma haematobium infection and with lower risk for allergic reactivity in children living in a rural area in Ghana.PLoS neglected tropical diseases · 2008Article
- Modulation of anaphylaxis by helminth-derived products in animal models.Current allergy and asthma reports · 2007Review
- Does early EBV infection protect against IgE sensitization?The Journal of allergy and clinical immunology · 2005Article
- Parasites-allergy paradox: Disease mediators or therapeutic modulators.Journal of microscopy and ultrastructureReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Westernized countries are suffering from an epidemic rise in immunologic disorders, such as childhood allergy. A popular explanation is that the increased prevalence in allergy is due to a diminished or altered exposure to gut-dwelling microbes, resulting in a disordered immunoregulation. Various population studies have provided a strong case for the involvement of helminth infections in this respect. Detailed analysis of helminth-induced immune responses showed that helminths not only prime for polarized Th2 responses but also potently induce T-cell hyporesponsiveness. Recently, it has been demonstrated that helminths induce suppressed host immune responses by the priming for regulatory T cells. It is proposed that this regulatory T cell-inducing activity accounts for the protection observed in the development of allergic disorders. It would be interesting to define and characterize particular helminth molecules that have profound immunomodulatory capacities as a target for therapeutic application in the treatment or prophylaxis of allergic manifestations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.