ArticleBMC bioinformatics2005
Modelling the correlation between the activities of adjacent genes in Drosophila.
Article in BMC bioinformatics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- A Catalogue of PutativeG3 (Bethesda, Md.) · 2018Article
- Gene silencing of porcine MUC13 and ITGB5: candidate genes towards Escherichia coli F4ac adhesion.PloS one · 2013Article
- Support for multiple classes of local expression clusters in Drosophila melanogaster, but no evidence for gene order conservation.Genome biology · 2011Article
- Neighbourhood continuity is not required for correct testis gene expression in Drosophila.PLoS biology · 2010Article
- Co-expression of neighboring genes in the zebrafish (Danio rerio) genome.International journal of molecular sciences · 2009Article
- Positive correlation between gene coexpression and positional clustering in the zebrafish genome.BMC genomics · 2009Article
- Complex organizational structure of the genome revealed by genome-wide analysis of single and alternative promoters in Drosophila melanogaster.BMC genomics · 2009Article
- Genome organization and gene expression shape the transposable element distribution in the Drosophila melanogaster euchromatin.PLoS genetics · 2007Article
- Co-expression of adjacent genes in yeast cannot be simply attributed to shared regulatory system.BMC genomics · 2007Article
- Principles of genome evolution in the Drosophila melanogaster species group.PLoS biology · 2007Article
- Evidence of spatially bound gene regulation in Mus musculus: decreased gene expression proximal to microRNA genomic location.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Lower expression of genes near microRNA in C. elegans germline.BMC bioinformatics · 2006Article
- Unusual linkage patterns of ligands and their cognate receptors indicate a novel reason for non-random gene order in the human genome.BMC evolutionary biology · 2005Article
- A non-random walk through the genome.Genome biology · 2005Review
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Authors and funding
2 authors.
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Abstract
backgroundCorrelation between the expression levels of genes which are located close to each other on the genome has been found in various organisms, including yeast, drosophila and humans. Since such a correlation could be explained by several biochemical, evolutionary, genetic and technological factors, there is a need for statistical models that correspond to specific biological models for the correlation structure.
resultsWe modelled the pairwise correlation between the expressions of the genes in a Drosophila microarray experiment as a normal mixture under Fisher's z-transform, and fitted the model to the correlations of expressions of adjacent as well as non-adjacent genes. We also analyzed simulated data for comparison. The model provided a good fit to the data. Further, correlation between the activities of two genes could, in most cases, be attributed to either of two factors: the two genes both being active in the same age group (adult or embryo), or the two genes being in proximity of each other on the chromosome. The interaction between these two factors was weak.
conclusionsCorrelation between the activities of adjacent genes is higher than between non-adjacent genes. In the data we analyzed, this appeared, for the most part, to be a constant effect that applied to all pairs of adjacent genes.
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