ArticleAmerican journal of human genetics2005
Association testing in a linked region using large pedigrees.
Article in American journal of human genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00059098 (Identification of Genes Predisposing to Atherosclerosis), which is not on this map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Identification of Genes Predisposing to Atherosclerosis
Who cites it
13 citing papers in PubMed.
- Article
- On the statistical properties of family-based association tests in datasets containing both pedigrees and unrelated case-control samples.European journal of human genetics : EJHG · 2012Article
- Review
- A gene frequency model for QTL mapping using Bayesian inference.Genetics, selection, evolution : GSE · 2010Article
- A narrow and highly significant linkage signal for severe bipolar disorder in the chromosome 5q33 region in Latin American pedigrees.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2009Article
- Bayesian quantitative trait locus mapping based on reconstruction of recent genetic histories.Genetics · 2009Article
- Statistical genetic approaches for mapping ophthalmic trait and disease genes.American journal of ophthalmology · 2009Article
- Exploring causality via identification of SNPs or haplotypes responsible for a linkage signal.Genetic epidemiology · 2007Article
- A logistic mixture model for a family-based association study.BMC proceedings · 2007Article
- High-resolution association mapping of quantitative trait loci: a population-based approach.Genetics · 2006Article
- Article
- Handling marker-marker linkage disequilibrium: pedigree analysis with clustered markers.American journal of human genetics · 2005Article
- Joint modeling of linkage and association: identifying SNPs responsible for a linkage signal.American journal of human genetics · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
This report describes computer implementation of a scheme for joint linkage and association analysis. The model implemented in the computer package Mendel estimates both recombination and linkage-disequilibrium parameters and conducts likelihood-ratio tests for (1) linkage alone, (2) linkage and association simultaneously, and (3) association in the presence of linkage. Application of the method to data from Finnish pedigrees with familial combined hyperlipidemia illustrates its potential for identification of associated SNP haplotypes in the presence of linkage. For the test results to be valid, good estimates of haplotype frequencies must be used in the analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.