ReviewEuropean journal of nuclear medicine and molecular imaging2005
Genetic and epigenetic features in radiation sensitivity Part I: cell signalling in radiation response.
Review in European journal of nuclear medicine and molecular imaging, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Cancer Effects of Low to Moderate Doses of Ionizing Radiation in Young People with Cancer-Predisposing Conditions: A Systematic Review.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Pooled it
- Association between Single Nucleotide Polymorphisms in XRCC3 and Radiation-Induced Adverse Effects on Normal Tissue: A Meta-Analysis.PloS one · 2015Pooled it
- Post-irradiation dietary restriction impairs hematopoiesis via inhibition of the pentose phosphate pathway in hematopoietic stem and progenitor cells.Cell death & disease · 2026Article
- Genome-wide DNA methylation regulation analysis provides novel insights on post-radiation breast cancer.Scientific reports · 2025Article
- Metachronous Occurrence of Acute Myeloid Leukaemia in a Case of Neuroendocrine Tumour.European journal of case reports in internal medicine · 2025Article
- Wireless radiation and health: making the case for proteomics research of individual sensitivity.Frontiers in public health · 2024Article
- HA15 inhibits binding immunoglobulin protein and enhances the efficacy of radiation therapy in esophageal squamous cell carcinoma.Cancer science · 2023Article
- Systemic oxidative stress to nucleic acids is unaltered following radioiodine therapy of patients with benign nodular goiter.European thyroid journal · 2015Article
- Differential DNA methylation analysis of breast cancer reveals the impact of immune signaling in radiation therapy.International journal of cancer · 2014Article
- Alternative medicine techniques have non-linear effects on radiation response and can alter the expression of radiation induced bystander effects.Dose-response : a publication of International Hormesis Society · 2013Article
- Use of the γ-H2AX assay to monitor DNA damage and repair in translational cancer research.Cancer letters · 2012Review
- A gene expression signature distinguishes normal tissues of sporadic and radiation-induced papillary thyroid carcinomas.British journal of cancer · 2012Article
- Typical cell signaling response to ionizing radiation: DNA damage and extranuclear damage.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2012Article
- Twilight effects of low doses of ionizing radiation on cellular systems: a bird's eye view on current concepts and research.Medical oncology (Northwood, London, England) · 2010Review
- Genetic variation in p53 and ATM haplotypes and risk of glioma and meningioma.Journal of neuro-oncology · 2007Article
- Genetic and epigenetic features in radiation sensitivity. Part II: implications for clinical practice and radiation protection.European journal of nuclear medicine and molecular imaging · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent progress especially in the field of gene identification and expression has attracted greater attention to genetic and epigenetic susceptibility to cancer, possibly enhanced by ionising radiation. It has been proposed that the occurrence and severity of the adverse reactions to radiation therapy are also influenced by such genetic susceptibility. This issue is especially important for radiation therapists since hypersensitive patients may suffer from adverse effects in normal tissues following standard radiation therapy, while normally sensitive patients could receive higher doses of radiation offering a better likelihood of cure for malignant tumours. This paper, the first of two parts, reviews the main mechanisms involved in cell response to ionising radiation. DNA repair machinery and cell signalling pathways are considered and their role in radiosensitivity is analysed. The implication of non-targeted and delayed effects in radiosensitivity is also discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.