ArticleMolecular and cellular biology2005
Common effects of acidic activators on large-scale chromatin structure and transcription.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 66 citations in OpenAlex.
- Acidic transcription factors position the genome at nuclear speckles through transcription-dependent and -independent mechanisms.Molecular cell · 2026Article
- Structural insights into p300 regulation and acetylation-dependent genome organisation.Nature communications · 2022Article
- Factors and Mechanisms That Influence Chromatin-Mediated Enhancer-Promoter Interactions and Transcriptional Regulation.Cancers · 2022Review
- Repression of Wnt/β-catenin signaling by SOX9 and Mastermind-like transcriptional coactivator 2.Science advances · 2021Article
- The SAGA chromatin-modifying complex: the sum of its parts is greater than the whole.Genes & development · 2020Review
- White spot syndrome viral protein VP9 alters the cellular higher-order chromatin structure.FASEB bioAdvances · 2020Article
- Recent advances in the spatial organization of the mammalian genome.Journal of biosciences · 2020Review
- Cockayne Syndrome: The many challenges and approaches to understand a multifaceted disease.Genetics and molecular biology · 2020Article
- Decreased Enhancer-Promoter Proximity Accompanying Enhancer Activation.Molecular cell · 2019Article
- LINE-1 activation after fertilization regulates global chromatin accessibility in the early mouse embryo.Nature genetics · 2017Article
- A fine LINE-1 in mouse embryonic chromatin regulation.Nature genetics · 2017Article
- Transcription upregulation via force-induced direct stretching of chromatin.Nature materials · 2016Article
- Replication timing and transcriptional control: beyond cause and effect-part III.Current opinion in cell biology · 2016Review
- Orc5 induces large-scale chromatin decondensation in a GCN5-dependent manner.Journal of cell science · 2016Article
- An H4K16 histone acetyltransferase mediates decondensation of the X chromosome inEpigenetics & chromatin · 2016Article
- Chromatin decondensation is sufficient to alter nuclear organization in embryonic stem cells.Science (New York, N.Y.) · 2014Article
- Targeted INO80 enhances subnuclear chromatin movement and ectopic homologous recombination.Genes & development · 2012Article
- Epigenetic engineering: histone H3K9 acetylation is compatible with kinetochore structure and function.Journal of cell science · 2012Article
- Reprogramming of mouse and human somatic cells by high-performance engineered factors.EMBO reports · 2011Article
- The fractal globule as a model of chromatin architecture in the cell.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Large-scale chromatin decondensation has been observed after the targeting of certain acidic activators to heterochromatic chromatin domains. Acidic activators are often modular, with two or more separable transcriptional activation domains. Whether these smaller regions are sufficient for all functions of the activators has not been demonstrated. We adapted an inducible heterodimerization system to allow systematic dissection of the function of acidic activators, individual subdomains within these activators, and short acidic-hydrophobic peptide motifs within these subdomains. Here, we demonstrate that large-scale chromatin decondensation activity is a general property of acidic activators. Moreover, this activity maps to the same acidic activator subdomains and acidic-hydrophobic peptide motifs that are responsible for transcriptional activation. Two copies of a mutant peptide motif of VP16 (viral protein 16) possess large-scale chromatin decondensation activity but minimal transcriptional activity, and a synthetic acidic-hydrophobic peptide motif had large-scale chromatin decondensation activity comparable to the strongest full-length acidic activator but no transcriptional activity. Therefore, the general property of large-scale chromatin decondensation shared by most acidic activators is not simply a direct result of transcription per se but is most likely the result of the concerted action of coactivator proteins recruited by the activators' short acidic-hydrophobic peptide motifs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.