ArticleThe Journal of cell biology2005
Generation of nonidentical compartments in vesicular transport systems.
Article in The Journal of cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 68 citations in OpenAlex.
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- Potential based, spatial simulation of dynamically nested particles.BMC bioinformatics · 2019Article
- Dynamic balance between vesicle transport and microtubule growth enables neurite outgrowth.PLoS computational biology · 2019Article
- Reconstruction of endosomal organization and function by a combination of ODE and agent-based modeling strategies.Biology direct · 2018Article
- Cargo induces retromer-mediated membrane remodeling on membranes.Molecular biology of the cell · 2018Article
- Trisomy 21 Represses Cilia Formation and Function.Developmental cell · 2018Article
- Stochastic Model of Maturation and Vesicular Exchange in Cellular Organelles.Biophysical journal · 2018Article
- Agents and networks to model the dynamic interactions of intracellular transport.Cellular logistics · 2017Article
- Nonequilibrium description of de novo biogenesis and transport through Golgi-like cisternae.Scientific reports · 2016Article
- Article
- Model of Growth Cone Membrane Polarization via Microtubule Length Regulation.Biophysical journal · 2015Article
- Models in biology: 'accurate descriptions of our pathetic thinking'.BMC biology · 2014Article
- Control systems and coordination protocols of the secretory pathway.F1000prime reports · 2014Review
- Synthetic biology outside the cell: linking computational tools to cell-free systems.Frontiers in bioengineering and biotechnology · 2014Review
- New organelles by gene duplication in a biophysical model of eukaryote endomembrane evolution.Biophysical journal · 2013Article
- A model for the self-organization of vesicular flux and protein distributions in the Golgi apparatus.PLoS computational biology · 2013Article
- The KDEL receptor couples to Gαq/11 to activate Src kinases and regulate transport through the Golgi.The EMBO journal · 2012Article
- Article
- Spatial modeling of vesicle transport and the cytoskeleton: the challenge of hitting the right road.PloS one · 2012Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How can organelles communicate by bidirectional vesicle transport and yet maintain different protein compositions? We show by mathematical modeling that a minimal system, in which the basic variables are cytosolic coats for vesicle budding and membrane-bound soluble N-ethyl-maleimide-sensitive factor attachment protein receptors (SNAREs) for vesicle fusion, is sufficient to generate stable, nonidentical compartments. A requirement for establishing and maintaining distinct compartments is that each coat preferentially packages certain SNAREs during vesicle budding. Vesicles fuse preferentially with the compartment that contains the highest concentration of cognate SNAREs, thus further increasing these SNAREs. The stable steady state is the result of a balance between this autocatalytic SNARE accumulation in a compartment and the distribution of SNAREs between compartments by vesicle budding. The resulting nonhomogeneous SNARE distribution generates coat-specific vesicle fluxes that determine the size of compartments. With nonidentical compartments established in this way, the localization and cellular transport of cargo proteins can be explained simply by their affinity for coats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.