Evidence map›Paper›PMID 15657389›Full record

ArticleThe Journal of cell biology2005

Going in GTP cycles in the nucleolus.

Tom Misteli

Abstract readComment
In one paragraph

Article in The Journal of cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. The nucleolus.Cold Spring Harbor perspectives in biology · 2011
    Review
  4. Article
  5. Proteomic analysis of bovine nucleolus.Genomics, proteomics & bioinformatics · 2010
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Tom MisteliNational Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. mistelit@mail.nih.gov

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proteins are directed to cellular compartments by specific localization signals. A GTP-driven cycle has now been identified as a mechanism for protein targeting to the nucleolus. The involvement of a GTP switch suggests that nucleolar localization can be regulated and may be responsive to extracellular stimuli via signaling pathways. The uncovered mechanism also implies that localization is determined by increased retention rather than directed targeting.

Indexed as

Carrier ProteinsCell NucleolusCell NucleusCell ProliferationGTP-Binding ProteinsGuanosine TriphosphateHumansIntranuclear SpaceModels, BiologicalNuclear ProteinsProtein BindingProtein TransportSignal TransductionCarrier ProteinsGNL3 protein, humanGTP-Binding ProteinsGuanosine TriphosphateNuclear Proteins

Identifiers

PMID15657389
PMCPMC2171599

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.