ArticleProceedings of the National Academy of Sciences of the United States of America1992
Thymidine kinase transcription is regulated at G1/S phase by a complex that contains retinoblastoma-like protein and a cdc2 kinase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 101 citations in OpenAlex.
- Relevance of pRB Loss in Human Malignancies.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022Review
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- A novel E2F-like protein involved in transcriptional activation of cyst wall protein genes in Giardia lamblia.The Journal of biological chemistry · 2011Article
- The spectra of large second-step mutations are similar for two different mouse autosomes.Mutation research · 2008Article
- Distinct recruitment of E2F family members to specific E2F-binding sites mediates activation and repression of the E2F1 promoter.Oncogene · 2003Article
- Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor.Genes & development · 2002Article
- Nucleocytoplasmic shuttling of p130/RBL2: novel regulatory mechanism.Molecular and cellular biology · 2002Article
- Article
- CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase.Molecular and cellular biology · 1999Article
- Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP.Genes & development · 1999Article
- Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F.Molecular and cellular biology · 1998Article
- Regulation of cellular genes in a chromosomal context by the retinoblastoma tumor suppressor protein.Molecular and cellular biology · 1998Article
- Rb binds c-Jun and activates transcription.The EMBO journal · 1998Article
- Transcriptional repression and growth suppression by the p107 pocket protein.Molecular and cellular biology · 1996Article
- Interaction of the 72-kilodalton human cytomegalovirus IE1 gene product with E2F1 coincides with E2F-dependent activation of dihydrofolate reductase transcription.Journal of virology · 1995Article
- The ATF site mediates downregulation of the cyclin A gene during contact inhibition in vascular endothelial cells.Molecular and cellular biology · 1995Article
- Development of the osteoblast phenotype: molecular mechanisms mediating osteoblast growth and differentiation.The Iowa orthopaedic journal · 1995Review
- Transcription of histone H4, H3, and H1 cell cycle genes: promoter factor HiNF-D contains CDC2, cyclin A, and an RB-related protein.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis.Molecular and cellular biology · 1994Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Transcription of the murine thymidine kinase gene, which is coregulated with the G1/S phase transition, is activated by changing the binding of protein complexes Yi1 and Yi2 to three upstream DNA motifs. Yi1 is replaced by Yi2 shortly before S phase. Yi1 contains a protein of 110 kDa that binds to the DNA motif sites and may be an underphosphorylated murine retinoblastoma protein, shown by its molecular mass, timing of its activity, and antibody recognition. An H1 kinase related to cdc2 cofractionates with both complexes. We propose that this kinase phosphorylates the murine retinoblastoma protein, releasing transcriptional inhibitions by Yi1 and permitting cell cycle progression. These results provide a cycle-related molecular target for such complexes. They are based on investigations of cycle control in uninfected cells. The Yi complexes are similar but not identical to complexes that include a cellular protein, E2F, that was originally found to bind to adenovirus DNA.
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