ArticleWorld journal of gastroenterology2005
Enhanced production of leptin in gastric fundic mucosa with Helicobacter pylori infection.
Article in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 49 citations in OpenAlex.
- Associations ofTherapeutic advances in gastroenterology · 2026Article
- Review
- Adipokines: masterminds of metabolic inflammation.Nature reviews. Immunology · 2025Review
- Role of Leptin in the Digestive System.Frontiers in pharmacology · 2021Review
- The Interaction ofAdvanced biomedical research · 2019Review
- Leptin Functions in Infectious Diseases.Frontiers in immunology · 2018Review
- The Possible Role ofFrontiers in microbiology · 2017Review
- Helicobacter pylori infection and diabetes: is it a myth or fact?World journal of gastroenterology · 2014Review
- Structure of the human gastric bacterial community in relation to Helicobacter pylori status.The ISME journal · 2011Article
- Helicobacter pylori infection as a risk factor for insulin resistance.Digestive diseases and sciences · 2009Article
- Helicobacter pylori infection and endocrine disorders: is there a link?World journal of gastroenterology · 2009Review
- Study of association between atrophic gastritis and body mass index: a cross-sectional study in 10,197 Japanese subjects.Digestive diseases and sciences · 2009Article
- Correlation between gastrointestinal symptoms and gastric leptin and ghrelin expression in patients with gastritis.Digestive diseases and sciences · 2007Article
- Effect of NaCl and Helicobacter pylori vacuolating cytotoxin on cytokine expression and viability.World journal of gastroenterology · 2006Article
- Concentrations of gastric mucosal cytokines in children with food allergy and Helicobacter pylori infection.World journal of gastroenterology · 2005Article
- Endothelin-1-dependent up-regulation of leptin production in gastric mucosal injury by indomethacin.Inflammopharmacology · 2005Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo determine the concentrations of leptin in plasma and gastric fundic mucosa in humans, with reference to Helicobacter pylori (H pylori) infection, and their association with gastric mucosal levels of interleukin (IL)-1beta, IL-6 and IL-8.
methodsPlasma leptin concentrations were determined in 135 outpatients with non-ulcer dyspepsia, consisting of 95 H pylori-infected and 40 uninfected subjects, and 13 patients before and after cure of the infection with anti-H pylori regimen. Using biopsy samples that were endoscopically obtained from the middle corpus along the greater curvature, gastric leptin contents were measured by radioimmunoassay and the mucosal concentrations of IL-1beta, IL-6 and IL-8 were measured by enzyme linked immunosorbent assay. We also analysed the expression of leptin in the fundic mucosa by reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemistry.
resultsThe mucosal levels of leptin in the fundic mucosa of H pylori-infected patients were significantly higher than those of uninfected patients. The amount of gastric leptin correlated positively with the mucosal levels of IL-1beta and IL-6, but not IL-8. Circulating leptin correlated with body mass index, but not with H pylori status, and there was no change in plasma leptin levels following cure of the infection. Leptin immunoreactive cells were noted in the lower half of the fundic glands, and its expression of messenger ribonucleic acid in the oxyntic mucosa was detected by RT-PCR.
conclusionLeptin production is enhanced in H pylori-infected gastric mucosa. Gastric leptin may be involved in immune and inflammatory response during H pylori infection, through interaction with proinflammatory cytokines.
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