ArticleBritish journal of pharmacology2005
Aldosterone does not mediate angiotensin II-induced atherosclerosis and abdominal aortic aneurysms.
Article in British journal of pharmacology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- Review
- Epithelial Sodium Channel in Aldosterone-Induced Endothelium Stiffness and Aortic Dysfunction.Hypertension (Dallas, Tex. : 1979) · 2018Article
- Cardiac magnetic resonance assessment of interstitial myocardial fibrosis and cardiomyocyte hypertrophy in hypertensive mice treated with spironolactone.Journal of the American Heart Association · 2014Article
- Mineralocorticoid receptor agonists induce mouse aortic aneurysm formation and rupture in the presence of high salt.Arteriosclerosis, thrombosis, and vascular biology · 2013Article
- Mineralocorticoid receptor antagonism inhibits vein graft remodeling in mice.The Journal of thoracic and cardiovascular surgery · 2013Article
- β-Arrestin-2 deficiency attenuates abdominal aortic aneurysm formation in mice.Circulation research · 2013Article
- Direct Renin Inhibitor Attenuates Left Ventricular Remodeling in Post-Myocardial Infarction Heart Failure Mice.Acta Cardiologica Sinica · 2013Article
- Aldosterone increases early atherosclerosis and promotes plaque inflammation through a placental growth factor-dependent mechanism.Journal of the American Heart Association · 2013Article
- Blood pressure response to angiotensin II is enhanced in obese Zucker rats and is attributed to an aldosterone-dependent mechanism.British journal of pharmacology · 2012Article
- 11β-hydroxysteroid dehydrogenase type 2 deficiency accelerates atherogenesis and causes proinflammatory changes in the endothelium in apoe-/- mice.Endocrinology · 2011Article
- Experimental models of abdominal aortic aneurysms.The open cardiovascular medicine journal · 2010Article
- Circulating neprilysin clears brain amyloid.Molecular and cellular neurosciences · 2010Article
- Complement regulator CD59 protects against angiotensin II-induced abdominal aortic aneurysms in mice.Circulation · 2010Article
- The role of aldosterone in mediating the dependence of angiotensin hypertension on IL-6.American journal of physiology. Regulatory, integrative and comparative physiology · 2009Article
- Expression of neprilysin in skeletal muscle reduces amyloid burden in a transgenic mouse model of Alzheimer disease.Molecular therapy : the journal of the American Society of Gene Therapy · 2009Article
- Peripherally expressed neprilysin reduces brain amyloid burden: a novel approach for treating Alzheimer's disease.Journal of neuroscience research · 2009Article
- Recent advances in molecular mechanisms of abdominal aortic aneurysm formation.World journal of surgery · 2008Review
- The role of the renin-angiotensin system in aortic aneurysmal diseases.Current hypertension reports · 2008Review
- Renin inhibition reduces hypercholesterolemia-induced atherosclerosis in mice.The Journal of clinical investigation · 2008Article
- Angiotensin II and abdominal aortic aneurysms.Current hypertension reports · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We have demonstrated previously that infusion of angiotensin II (AngII) into hyperlipidemic mice augments atherosclerosis and results in the formation of abdominal aortic aneurysms (AAA). The purpose of this study was to determine the role of aldosterone in these AngII-induced vascular pathologies. Male apolipoprotein E-/- (apoE) mice were infused with either vehicle or aldosterone (50 or 200 ng kg(-1) min(-1)). Arterial blood pressure was determined throughout the study and serum lipid concentrations and vascular pathology were quantified after 28 days of infusion. Infusion of aldosterone did not influence body weight or serum cholesterol concentrations. Kidney weight was increased dose-dependently by aldosterone infusion. Systolic blood pressure was not significantly altered by aldosterone. Plasma aldosterone concentrations were increased dose-dependently by infusion of aldosterone. However, there was no effect of aldosterone on the extent of atherosclerosis and AAAs were not formed. Implantation of pellets containing spironolactone (16 mg kg(-1) day(-1)) in AngII-infused apoE-/- mice (1000 ng kg(-1) min(-1)) had no effect on AngII-induced elevations in blood pressure. Plasma aldosterone concentration was not influenced by coadministration of spironolactone with AngII. Spironolactone administration did not influence the extent of atherosclerosis. Moreover, spironolactone had no significant effect on AngII-induced AAA (incidence of AAA formation: 80 versus 70% for vehicle versus spironolactone, respectively; not significant). These studies demonstrate that the AngII-induced vascular pathologies of atherosclerosis and AAA formation are not mediated through aldosterone.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.