ReviewMolecular neurobiology2004
Nuclear receptor coregulators are new players in nervous system development and function.
Review in Molecular neurobiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 37 citations in OpenAlex.
- Epigenetic regulation of nuclear receptors: Implications for endocrine-related diseases and therapeutic strategies.Genes & diseases · 2025Review
- Mechanisms of NURR1 Regulation: Consequences for Its Biological Activity and Involvement in Pathology.International journal of molecular sciences · 2023Review
- E6AP in the brain: one protein, dual function, multiple diseases.Molecular neurobiology · 2014Article
- Sex differences in DNA methylation may contribute to risk of PTSD and depression: a review of existing evidence.Depression and anxiety · 2013Review
- Progesterone and estradiol effects on SRC-1 and SRC-3 expression in human astrocytoma cell lines.Endocrine · 2010Article
- Who's in charge? Nuclear receptor coactivator and corepressor function in brain and behavior.Frontiers in neuroendocrinology · 2009Review
- Nuclear receptors as therapeutic targets in cholestatic liver diseases.British journal of pharmacology · 2009Review
- Thyroid hormone components are expressed in three sequential waves during development of the chick retina.BMC developmental biology · 2008Article
- Sex steroid-related candidate genes in psychiatric disorders.Journal of psychiatry & neuroscience : JPN · 2008Review
- An overview of nuclear receptor coregulators involved in cerebellar development.Cerebellum (London, England) · 2008Review
- SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron.Nature · 2007Article
- Crx activates opsin transcription by recruiting HAT-containing co-activators and promoting histone acetylation.Human molecular genetics · 2007Article
- Cells in behaviourally relevant brain regions coexpress nuclear receptor coactivators and ovarian steroid receptors.Journal of neuroendocrinology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Steroid/thyroid hormones and their cognate nuclear receptors (NRs) play important roles in nervous system development and function. The spatial and temporal gene expression that is regulated by NRs in the nervous system requires transcriptional intermediary coregulators, designated as coactivators and corepressors. These coregulators enhance or repress transcriptional activity of NRs and modulate their target gene transcription. Recent progress has largely advanced our understanding of the molecular mechanisms by which NR coregulators function in the nervous system. This article summarizes our current knowledge about the molecular mechanisms, expression patterns, and biological functions of NR coactivators, such as the p160 steroid receptor coactivator family, CBP, p300, BRG1, TRAP220, PGC-1alpha, ERAP140, NIX1, and E6-AP, as well as corepressors such as NCoR and SMRT. Accumulated findings suggest that the functional spectrum of NR coregulators is much broader than was initially speculated, and these coregulators likely contribute to many physiological aspects of nervous system development and function.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.