ReviewMolecular neurobiology2004
Molecular mechanism of scorpion neurotoxins acting on sodium channels: insight into their diverse selectivity.
Review in Molecular neurobiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 53 citations in OpenAlex.
- Animal Venoms as Potential Source of Anticonvulsants.F1000Research · 2024Review
- Brain natriuretic peptide suppresses pain induced by BmK I, a sodium channel-specific modulator, in rats.The journal of headache and pain · 2016Article
- Scorpion toxin BmK I directly activates Nav1.8 in primary sensory neurons to induce neuronal hyperexcitability in rats.Protein & cell · 2015Article
- Defined nanoscale chemistry influences delivery of peptido-toxins for cancer therapy.PloS one · 2015Article
- Scorpion venom components that affect ion-channels function.Toxicon : official journal of the International Society on Toxinology · 2013Review
- Pharmacological kinetics of BmK AS, a sodium channel site 4-specific modulator on Nav1.3.Neuroscience bulletin · 2012Article
- Mining the virgin land of neurotoxicology: a novel paradigm of neurotoxic peptides action on glycosylated voltage-gated sodium channels.Journal of toxicology · 2012Article
- Exploring the obscure profiles of pharmacological binding sites on voltage-gated sodium channels by BmK neurotoxins.Protein & cell · 2011Review
- Manipulating neuronal circuits with endogenous and recombinant cell-surface tethered modulators.Frontiers in molecular neuroscience · 2009Article
- Anticonvulsant effect of BmK IT2, a sodium channel-specific neurotoxin, in rat models of epilepsy.British journal of pharmacology · 2008Article
- Leftward shift in the voltage-dependence for Ca2+ currents activation induced by a new toxin from Phoneutria reidyi (Aranae, Ctenidae) venom.Cellular and molecular neurobiology · 2007Article
- Voltage-gated sodium channel modulation by scorpion alpha-toxins.Toxicon : official journal of the International Society on Toxinology · 2007Review
- Chinese-scorpion (Buthus martensi Karsch) toxin BmK alphaIV, a novel modulator of sodium channels: from genomic organization to functional analysis.The Biochemical journal · 2006Article
- Characterization of Functional Effects of Two New Active Fractions Isolated From Scorpion Venom on Neuronal CaBasic and clinical neuroscienceArticle
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Scorpion toxins that affect sodium channel gating traditionally are divided into alpha- and beta-classes. They show vast diversity in their selectivity for phyletic- or isoform-specific sodium channels. This article discusses the molecular mechanism of the selectivity. Moreover, a phylogenetic tree of scorpion toxins has been constructed, which, together with the worldwide distribution of toxins and the zoogeographic dispersion of the studied genera, offers an insight into the evolution of diverse scorpion toxins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.