ArticleClinical and experimental immunology2005
Excessive expression of Txk, a member of the Tec family of tyrosine kinases, contributes to excessive Th1 cytokine production by T lymphocytes in patients with Behcet's disease.
Article in Clinical and experimental immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 46 citations in OpenAlex.
- The Role of Viral and Bacterial Infections in the Etiology of Behçet's Disease.Journal of clinical laboratory analysis · 2026Review
- Mitochondrial DNA 3243 mutation may be associated with positivity of zinc transporter 8 autoantibody in cases of slowly progressive type 1 diabetes mellitus.Diabetology international · 2025Article
- T helper type 1-related molecules as well as interleukin-15 are hyperexpressed in the skin lesions of patients with pyoderma gangrenosum.Clinical and experimental immunology · 2017Article
- Possible association of proinflammatory cytokines including IL1β and TNFα with enhanced Th17 cell differentiation in patients with Behcet's disease.Clinical rheumatology · 2016Article
- Pathogenesis of Behçet's disease: autoinflammatory features and beyond.Seminars in immunopathology · 2015Review
- Immunopathogenic Role of Herpes Simplex Virus in Behçet's Disease.Genetics research international · 2013Review
- Skewed Helper T-Cell Responses to IL-12 Family Cytokines Produced by Antigen-Presenting Cells and the Genetic Background in Behcet's Disease.Genetics research international · 2013Review
- Excessive CD4+ T cells co-expressing interleukin-17 and interferon-γ in patients with Behçet's disease.Clinical and experimental immunology · 2012Article
- Aberrant Activation of Heat Shock Protein 60/65 Reactive T Cells in Patients with Behcet's Disease.Autoimmune diseases · 2012Article
- Selective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responses.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- HSP60 and anti-HSP60 antibodies in vasculitis: they are two of a kind.Clinical reviews in allergy & immunology · 2008Review
- S-antigen specific T helper type 1 response is present in Behcet's disease.Molecular vision · 2008Article
- Involvement of innate immunity in the pathogenesis of intestinal Behçet's disease.Clinical and experimental immunology · 2008Article
- High incidence of morphological myelodysplasia and apoptotic bone marrow cells in Behçet's disease.Journal of clinical immunology · 2007Article
- Nicotine inhibits the production of proinflammatory mediators in human monocytes by suppression of I-kappaB phosphorylation and nuclear factor-kappaB transcriptional activity through nicotinic acetylcholine receptor alpha7.Clinical and experimental immunology · 2006Article
- Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease.Clinical medicine & research · 2006Review
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Excessive Th1 cell function is importantly involved in the pathogenesis of Behcet's disease (BD). We previously found that Txk, a member of the Tec family of tyrosine kinases, acts as a Th1 cell specific transcription factor. To investigate immune aberration in the pathogenesis of BD, we studied the expression of Txk and Th1 cytokines in peripheral blood lymphocytes (PBL) and skin lesions in patients with BD. Cytokine production by the lymphocytes was assessed using ELISA. PBL produced excessive Th1 associated cytokines including IFN-gamma and IL-12 spontaneously and in response to exogenous HSP60-derived peptide stimulation, which was shown to induce proliferation of PBL, in patients with BD. Circulating CD4+ T cells expressed excessive Txk protein. A majority of cells infiltrating into skin lesions expressed IFN-gamma in the BD specimens. IL-12 and IL-18 were also expressed in the mononuclear cell aggregates. Lymphocytes accumulating in the skin lesion expressed higher levels of Txk as compared with atopic dermatitis lesions, a typical Th2 disease. IFN-gamma, IL-18 and Il-12 were detected in the BD skin lesions, which may induce preferential development of Th1 cells in patients with BD. The mononuclear cell aggregates contained Txk expressing cells in such skin lesions. Collectively, Txk expressing Th1 cells and the Th1 associated cytokines may play a critical role in the development of skin lesions in BD.
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