ArticleClinical and experimental immunology2005
T cell repertoire in patients with stable scleroderma.
Article in Clinical and experimental immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Characterising the autoantibody repertoire in systemic sclerosis following myeloablative haematopoietic stem cell transplantation.Annals of the rheumatic diseases · 2023Article
- Lymphocyte subset abnormalities in early severe scleroderma favor a Th2 phenotype and are not altered by prior immunosuppressive therapy.Rheumatology (Oxford, England) · 2022Article
- CD8International journal of molecular sciences · 2022Review
- A Mechanistic Insight into the Pathogenic Role of Interleukin 17A in Systemic Autoimmune Diseases.Mediators of inflammation · 2022Review
- Article
- Current perspectives on the role of CD8+ T cells in systemic sclerosis.Immunology letters · 2018Review
- Interstitial lung disease in systemic sclerosis: current and future treatment.Rheumatology international · 2017Review
- Subset-specific alterations in frequencies and functional signatures of γδ T cells in systemic sclerosis patients.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Article
- Association of immunological cell profiles with specific clinical phenotypes of scleroderma disease.BioMed research international · 2014Article
- Missing: a diagnostic technique to enumerate antigen-specific T cells.Critical reviews in oncology/hematology · 2012Review
- T cells and B cells in the pathogenesis of systemic sclerosis: recent insights and therapeutic opportunities.Current rheumatology reports · 2006Review
- Peripheral T lymphocytes from patients with early systemic sclerosis co-cultured with autologous fibroblasts undergo an oligoclonal expansion similar to that occurring in the skin.Clinical and experimental immunology · 2006Article
- Oligoclonal CD4+ T cells in the lungs of patients with severe emphysema.American journal of respiratory and critical care medicine · 2005Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
At onset of systemic sclerosis (SSc), T cells have been found to oligoclonally expand in the skin, presumably in response to auto-antigens, but the T cell repertoire has not been evaluated at a later stage. To determine whether a perpetuating immune response contributes to the pathogenesis of stable SSc, the T cell repertoire was analysed in patients with diffuse (d) or limited (l) SSc, and compared to patients with primary Raynaud's phenomenon (RP) or healthy volunteers (Ctrl). The T cell repertoire (total, CD4 or CD8 sorted blood T cells) was analysed by qualitative and quantitative immunoscope (14 BV families analysed) in 11 untreated dSSc and 11 untreated lSSc, 10 RP and 11 Ctrl. To better detect in vivo activated cells, repertoire analysis was also performed on sorted CD4 T cells after in vitro culture with IL-2. In parallel, 6 skin biopsies from SSc patients were analysed. After 7-8 years of disease evolution, SSc patients did not show detectable clonal T cell expansions in the skin, even after tentative expansion from the biopsy with IL-2. Total T cell, sorted CD4 and CD8 T cell repertoires from the blood of patients with SSc did not show significant perturbation as compared to patients with RP and Ctrl. After IL-2 culture for 7 days, blood CD4 T cells from the patients did not preferentially expand as compared to RP and Ctrl. These findings suggest that antigen-driven immune responses may play a lesser role in established SSc than at disease onset.
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