ArticleGenetics2005
Linkage disequilibrium and recent selection at three immunity receptor loci in Drosophila simulans.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- A test for selection employing quantitative trait locus and mutation accumulation data.Genetics · 2012Article
- Adaptive evolution of a novel Drosophila lectin induced by parasitic wasp attack.Molecular biology and evolution · 2012Article
- The effect of recurrent mutation on the linkage disequilibrium under a selective sweep.Journal of mathematical biology · 2012Article
- Host plant quality, selection history and trade-offs shape the immune responses of Manduca sexta.Proceedings. Biological sciences · 2011Article
- Haplotype structure and expression divergence at the Drosophila cellular immune gene eater.Molecular biology and evolution · 2010Article
- Article
- Low linkage disequilibrium in wild Anopheles gambiae s.l. populations.BMC genetics · 2010Article
- Evidence that adaptation in Drosophila is not limited by mutation at single sites.PLoS genetics · 2010Article
- Positively selected disease response orthologous gene sets in the cereals identified using Sorghum bicolor L. Moench expression profiles and comparative genomics.Molecular biology and evolution · 2009Article
- Clustering of Drosophila melanogaster immune genes in interplay with recombination rate.PloS one · 2008Article
- Natural selection on the Drosophila antimicrobial immune system.Current opinion in microbiology · 2008Review
- Population genomics: whole-genome analysis of polymorphism and divergence in Drosophila simulans.PLoS biology · 2007Article
- Unusual pattern of nucleotide sequence variation at the OS-E and OS-F genomic regions of Drosophila simulans.Genetics · 2007Article
- Soft sweeps III: the signature of positive selection from recurrent mutation.PLoS genetics · 2006Article
- Elevated polymorphism and divergence in the class C scavenger receptors of Drosophila melanogaster and D. simulans.Genetics · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immune system genes in a California population sample of Drosophila simulans were shown to bear several hallmarks of the effects of past directional selection. One potential effect of directional selection is an increase in linkage disequilibrium among the polymorphic sites that are linked to the site under selection. In this study, we focus on three D. simulans immunity loci, Hmu, Sr-CI/Sr-CIII, and Tehao, for which the polymorphic sites are in nearly perfect linkage disequilibrium, an unusual finding even with respect to other immunity genes sampled from the same lines. The most likely explanation for this finding is that, at each locus, two divergent alleles have been selected to intermediate frequencies in the recent past. The extent to which the linkage disequilibrium extends to the flanks of each of the immunity genes is minimal, suggesting that the favored mutations actually occurred within the immunity genes themselves. Furthermore, the excess linkage disequilibrium found in the California population is not found in an African D. simulans population sample and may be a result of novel pathogen-mediated selection pressures encountered during establishment of non-African populations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.