ArticleGenetics2005
Insertion/deletion and nucleotide polymorphism data reveal constraints in Drosophila melanogaster introns and intergenic regions.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 48 citations in OpenAlex.
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- The Impact of Natural Selection on Short Insertion and Deletion Variation in the Great Tit Genome.Genome biology and evolution · 2019Article
- The impact of poly-A microsatellite heterologies in meiotic recombination.Life science alliance · 2019Article
- High nucleotide diversity and limited linkage disequilibrium in Helicoverpa armigera facilitates the detection of a selective sweep.Heredity · 2015Article
- The effects of purifying selection on patterns of genetic differentiation between Drosophila melanogaster populations.Heredity · 2015Article
- Development of genetic markers in Eucalyptus species by target enrichment and exome sequencing.PloS one · 2015Article
- Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines.Genome research · 2014Article
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- Naturally occurring deletions of hunchback binding sites in the even-skipped stripe 3+7 enhancer.PloS one · 2014Article
- Strong heterogeneity in mutation rate causes misleading hallmarks of natural selection on indel mutations in the human genome.Molecular biology and evolution · 2014Article
- Abundance and distribution of transposable elements in two Drosophila QTL mapping resources.Molecular biology and evolution · 2013Article
- Stabilizing selection, purifying selection, and mutational bias in finite populations.Genetics · 2013Article
- Strong mutational bias toward deletions in the Drosophila melanogaster genome is compensated by selection.Genome biology and evolution · 2013Article
- Hsp90 is important for fecundity, longevity, and buffering of cryptic deleterious variation in wild fly populations.BMC evolutionary biology · 2012Article
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- Massive turnover of functional sequence in human and other mammalian genomes.Genome research · 2010Article
- Assessing the influence of adjacent gene orientation on the evolution of gene upstream regions in Arabidopsis thaliana.Genetics · 2010Article
- On the utility of short intron sequences as a reference for the detection of positive and negative selection in Drosophila.Molecular biology and evolution · 2010Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our study of nucleotide sequence and insertion/deletion polymorphism in Drosophila melanogaster noncoding DNA provides evidence for selective pressures in both intergenic regions and introns (of the large size class). Intronic and intergenic sequences show a similar polymorphic deletion bias. Insertions have smaller sizes and higher frequencies than deletions, supporting the hypothesis that insertions are selected to compensate for the loss of DNA caused by deletion bias. Analysis of a simple model of selective constraints suggests that the blocks of functional elements located in intergenic sequences are on average larger than those in introns, while the length distribution of relatively unconstrained sequences interspaced between these blocks is similar in intronic and intergenic regions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.