ArticleBiophysical journal2005
Contribution of hydrophobicity to thermodynamics of ligand-DNA binding and DNA collapse.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 69 citations in OpenAlex.
- Article
- A polymeric approach toward resistance-resistant antimicrobial agent with dual-selective mechanisms of action.Science advances · 2021Article
- Linking Temperature, Cation Concentration and Water Activity for the B to Z Conformational Transition in DNA.Molecules (Basel, Switzerland) · 2018Article
- The Length of Hydrophobic Chain in Amphiphilic Polypeptides Regulates the Efficiency of Gene Delivery.Polymers · 2018Article
- A histone-like protein induces plasmid DNA to form liquid crystals in vitro and gene compaction in vivo.International journal of molecular sciences · 2013Article
- Precision templating with DNA of a virus-like particle with peptide nanostructures.Journal of the American Chemical Society · 2013Article
- A universal description for the experimental behavior of salt-(in)dependent oligocation-induced DNA condensation.Nucleic acids research · 2012Article
- The C terminus of tubulin, a versatile partner for cationic molecules: binding of Tau, polyamines, and calcium.The Journal of biological chemistry · 2011Article
- Drug delivery trends in clinical trials and translational medicine: challenges and opportunities in the delivery of nucleic acid-based therapeutics.Journal of pharmaceutical sciences · 2011Review
- Multiplexed supramolecular self-assembly for non-viral gene delivery.Biomaterials · 2010Article
- Thermodynamics of polyethylenimine-DNA binding and DNA condensation.Biophysical journal · 2010Article
- Fatty acid-spermine conjugates as DNA carriers for nonviral in vivo gene delivery.Gene therapy · 2009Article
- A universal description for the experimental behavior of salt-(in)dependent oligocation-induced DNA condensation.Nucleic acids research · 2009Article
- Binding and clustering of glycosaminoglycans: a common property of mono- and multivalent cell-penetrating compounds.Biophysical journal · 2008Article
- Lipoplexes formed by DNA and ferrocenyl lipids: effect of lipid oxidation state on size, internal dynamics, and zeta-potential.Biophysical journal · 2007Article
- Sequence and length dependent thermodynamic differences in heterocyclic diamidine interactions at AT base pairs in the DNA minor groove.Biophysical chemistry · 2007Article
- Physicochemical properties affecting lipofection potency of a new series of 1,2-dialkoylamidopropane-based cationic lipids.Colloids and surfaces. B, Biointerfaces · 2007Article
- Ligand-induced DNA condensation: choosing the model.Biophysical journal · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The importance of understanding the dynamics of DNA condensation is inherent in the biological significance of DNA packaging in cell nuclei, as well as for gene therapy applications. Specifically, the role of ligand hydrophobicity in DNA condensation has received little attention. Considering that only multivalent cations can induce true DNA condensation, previous studies exploring monovalent lipids have been unable to address this question. In this study we have elucidated the contribution of the hydrophobic effect to multivalent cation- and cationic lipid-DNA binding and DNA collapse by studying the thermodynamics of cobalt hexammine-, spermine-, and lipospermine-plasmid DNA binding at different temperatures. Comparable molar heat capacity changes (DeltaC(p)) associated with cobalt hexammine- and spermine-DNA binding (-23.39 cal/mol K and -17.98 cal/mol K, respectively) suggest that upon binding to DNA, there are insignificant changes in the hydration state of the methylene groups in spermine. In contrast, the acyl chain contribution to the DeltaC(p) of lipospermine-DNA binding (DeltaC(p ) = DeltaC(p lipospermine) - DeltaC(p spermine)) is significant (-220.94 cal/mol K). Although lipopermine induces DNA ordering into "tubular" suprastructures, such structures do not assume toroidal dimensions as observed for spermine-DNA complexes. We postulate that a steric barrier posed by the acyl chains in lipospermine precludes packaging of DNA into dimensions comparable to those found in nature.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.