Evidence map›Paper›PMID 15653543›Full record

Trial reportJournal of dairy science2005

Immune parameters of dry cows fed mannan oligosaccharide and subsequent transfer of immunity to calves.

S T Franklin, M C Newman, K E Newman, K I Meek

Open access · bronzeAbstract readClinical TrialRandomized Controlled Trial
In one paragraph

Trial report in Journal of dairy science, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 133 citations in OpenAlex.

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  10. Deploying anMicrobiology spectrum · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

S T FranklinAnimal Sciences Department University of Kentucky, Lexington 40546-0215, USA. sfrankli@uky.edu
M C Newman
K E Newman
K I Meek
University of Kentucky · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this study was to evaluate the benefits of supplementation of mannan oligosaccharide (MOS) to cows during the last 3 wk of the dry period on immune function of the cows and subsequent transfer of passive immunity to their calves. Indicators of nonspecific and specific immunity were evaluated. Cows were vaccinated against rotavirus at 4 and 2 wk before expected parturition. Blood samples were obtained from cows before vaccination and at weekly intervals until calving and from calves at birth and 24 h for analysis of serum protein concentrations, packed cell volume, white blood cell counts, white blood cell differentials, and serum rotavirus neutralization titers. Colostrum quantity and quality were measured at calving, and immunoglobulin isotype concentrations in colostrum were determined. Specific immunity was enhanced by MOS supplementation as evidenced by greater serum rotavirus neutralization titers at calving in cows supplemented with MOS compared with control cows. Colostral rotavirus neutralization titers were not affected by treatment. Although numerical differences appeared large, there was a high degree of variability in the colostral rotavirus neutralization titers. Calves from cows fed MOS tended to have greater serum rotavirus neutralization titers compared with calves from cows fed the control diet. There was a tendency for greater increases in serum protein concentrations from birth to 24 h in calves from cows fed MOS compared with calves from cows fed the control diet. Results indicate that supplementation of MOS to cows during the dry period enhanced their immune response to rotavirus and tended to enhance the subsequent transfer of rotavirus antibodies to calves.

Indexed as

DietImmunity, Maternally-AcquiredAnimalsBlood ProteinsCattleColostrumErythrocyte IndicesFemaleImmunoglobulin AImmunoglobulin GImmunoglobulinsLactationLeukocyte CountMannansOligosaccharidesPregnancyBlood ProteinsImmunoglobulin AImmunoglobulin GImmunoglobulinsMannansOligosaccharides

Identifiers

PMID15653543
PMCPMC7190086
OpenAlexW2134065639

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.