Evidence map›Paper›PMID 15653305›Full record

ReviewCurrent opinion in immunology2005

Ligand recognition by antigen-presenting cell C-type lectin receptors.

Eamon P McGreal, Joanna L Miller, Siamon Gordon

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 306 citations in OpenAlex.

  1. Trial
  2. Article
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  7. Turkish journal of biology = Turk biyoloji dergisi · 2025
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Macrophage Gal/GalNAc lectin 2 (MGL2)Scientific reports · 2022
    Article
  15. Article
  16. Review
  17. GANAB andInternational journal of molecular sciences · 2022
    Review
  18. Review
  19. Review
  20. Article

48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Eamon P McGrealSir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
Joanna L Miller
Siamon Gordon
University of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is now appreciated that the range of ligands interacting with C-type lectin type receptors on antigen presenting cells includes endogenous self-molecules as well as pathogens and pathogen-derived ligands. Interestingly, not all interactions between these receptors and pathogenic ligands have beneficial outcomes, and it appears that some pathogens have evolved immunoevasive or immunosuppressive activities through receptors such as DC-SIGN. In addition to this, recent data indicate that the well-characterised macrophage mannose receptor is not essential to host defence against fungal pathogens, as previously thought, but has an important role in regulating endogenous glycoprotein clearance. New studies have also demonstrated that different ligand binding and/or sensing receptors collaborate for full and effective immune responses.

Indexed as

AnimalsAntigen PresentationBacterial ProteinsCell Adhesion MoleculesDC-Specific ICAM-3 Grabbing NonintegrinGlycoproteinsHumansLectins, C-TypeLigandsMacrophagesMannose-Binding LectinsMannose ReceptorReceptors, Cell SurfaceSignal TransductionBacterial ProteinsCell Adhesion MoleculesDC-Specific ICAM-3 Grabbing NonintegrinGlycoproteinsLectins, C-TypeLigandsMannose-Binding LectinsMannose ReceptorReceptors, Cell Surface

Identifiers

PMID15653305
PMCPMC7126011
OpenAlexW1968830740

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.