ArticleBMC genetics2005
Variants in the vitamin D receptor gene and asthma.
Article in BMC genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 72 citations in OpenAlex.
- Genome-wide association analysis of circulating vitamin D levels in children with asthma.Human genetics · 2012Trial
- Association Between VDR and CYP24A1 Polymorphisms, Atopic Dermatitis, and Biochemical Lipid and Vitamin D Profiles in Spanish Population: Case-Control Study.JMIR dermatology · 2023Article
- Association between Single Nucleotide Polymorphisms Related to Vitamin D Metabolism and the Risk of Developing Asthma.Nutrients · 2023Article
- Pre- and Postnatal Vitamin D Status and Allergy Outcomes in Early Childhood.Biomedicines · 2022Review
- Dietary Factors Associated with Asthma Development: A Narrative Review and Summary of Current Guidelines and Recommendations.Journal of asthma and allergy · 2022Review
- Association of Vitamin D receptor gene polymorphisms and clinical/severe outcomes of COVID-19 patients.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2021Article
- Differential distribution in vitamin D receptor gene variants and expression profile in Northeast Brazil influences upon active pulmonary tuberculosis.Molecular biology reports · 2020Article
- Association of vitamin D genetic pathway with asthma susceptibility in the Kurdish population.Journal of clinical laboratory analysis · 2020Article
- The Vitamin D Receptor Gene Polymorphisms in Asthmatic Children: A Case-Control Study.Pediatric allergy, immunology, and pulmonology · 2019Article
- Identification of Novel Biomarkers for Drug Hypersensitivity After Sequencing of the Promoter Area in 16 Genes of the Vitamin D Pathway and the High-Affinity IgE Receptor.Frontiers in genetics · 2019Article
- Role of CYP24A1, VDR and GC gene polymorphisms on deferasirox pharmacokinetics and clinical outcomes.The pharmacogenomics journal · 2018Article
- Immunomodulation by vitamin D.Allergologie select · 2018Article
- Sequence analysis of four vitamin D family genes (VDR, CYP24A1, CYP27B1 and CYP2R1) in Vogt-Koyanagi-Harada (VKH) patients: identification of a potentially pathogenic variant in CYP2R1.BMC ophthalmology · 2016Article
- Asthma: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases.Annals of the American Thoracic Society · 2014Review
- VDR attenuates acute lung injury by blocking Ang-2-Tie-2 pathway and renin-angiotensin system.Molecular endocrinology (Baltimore, Md.) · 2013Article
- Vitamin D and asthma.Dermato-endocrinology · 2012Article
- Fat-soluble vitamins and atopic disease: what is the evidence?The Proceedings of the Nutrition Society · 2012Review
- Vitamin D binding protein variants associate with asthma susceptibility in the Chinese Han population.BMC medical genetics · 2011Article
- Associations between genetic variants in vitamin D metabolism and asthma characteristics in young African Americans: a pilot study.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2011Article
- Vitamin D, the immune system and asthma.Expert review of clinical immunology · 2009Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEarly lifetime exposure to dietary or supplementary vitamin D has been predicted to be a risk factor for later allergy. Twin studies suggest that response to vitamin D exposure might be influenced by genetic factors. As these effects are primarily mediated through the vitamin D receptor (VDR), single base variants in this gene may be risk factors for asthma or allergy.
results951 individuals from 224 pedigrees with at least 2 asthmatic children were analyzed for 13 SNPs in the VDR. There was no preferential transmission to children with asthma. In their unaffected sibs, however, one allele in the 5' region was 0.5-fold undertransmitted (p = 0.049), while two other alleles in the 3' terminal region were 2-fold over-transmitted (p = 0.013 and 0.018). An association was also seen with bronchial hyperreactivity against methacholine and with specific immunoglobulin E serum levels.
conclusionThe transmission disequilibrium in unaffected sibs of otherwise multiple-affected families seem to be a powerful statistical test. A preferential transmission of vitamin D receptor variants to children with asthma could not be confirmed but raises the possibility of a protective effect for unaffected children.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.