ArticleImmunogenetics2005
Variable domains and a VpreB-like molecule are present in a jawless vertebrate.
Article in Immunogenetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- An inhibitory receptor of VLRB in the agnathan lamprey.Scientific reports · 2016Article
- Evolution of two prototypic T cell lineages.Cellular immunology · 2015Article
- Non-mammalian model systems for studying neuro-immune interactions after spinal cord injury.Experimental neurology · 2014Review
- A VpreB3 homologue in a marsupial, the gray short-tailed opossum, Monodelphis domestica.Immunogenetics · 2012Article
- The mouse B cell-specific mb-1 gene encodes an immunoreceptor tyrosine-based activation motif (ITAM) protein that may be evolutionarily conserved in diverse species by purifying selection.Molecular biology reports · 2012Article
- Genome biology of the cyclostomes and insights into the evolutionary biology of vertebrate genomes.Integrative and comparative biology · 2010Article
- Origin and evolution of the vertebrate leukocyte receptors: the lesson from tunicates.Immunogenetics · 2009Article
- Evolution and development of immunological structures in the lamprey.Current opinion in immunology · 2007Review
- Immunoglobulin variable regions in molecules exhibiting characteristics of innate and adaptive immune receptors.Immunologic research · 2007Article
- Blurring borders: innate immunity with adaptive features.Clinical & developmental immunology · 2007Review
- Ancient phylogenetic beginnings of immunoglobulin hypermutation.Journal of molecular evolution · 2006Article
- Ancient divergence of a complex family of immune-type receptor genes.Immunogenetics · 2006Article
- Variable domains in hagfish: NICIR is a polymorphic multigene family expressed preferentially in leukocytes and is related to lamprey TCR-like.Immunogenetics · 2006Article
- Reconstructing immune phylogeny: new perspectives.Nature reviews. Immunology · 2005Review
- The Toll-like receptors: analysis by forward genetic methods.Immunogenetics · 2005Review
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
Immunoglobulins (Igs) and T cell antigen receptors (TCRs) that undergo somatic diversification have not been identified in the two extant orders of jawless vertebrates, which occupy essential positions in terms of understanding the evolution of the emergence of adaptive immunity. Using a single motif-dependent PCR-based approach coupled with a vector that allows selection of cDNAs encoding secretion signal sequences, four different genes encoding Ig V-type domains were identified in the sea lamprey (Petromyzon marinus). One of the predicted proteins encoded by these genes shares structural characteristics with mammalian VpreB molecules, including the absence of a recognizable transmembrane region, a relatively high proportion of charged amino acids in its C-terminal tail and distinctive features of its secretion signal peptide. This is the first indication of a molecule related to the B cell receptor (BCR) complex in a species that diverged prior to the jawed vertebrates in which RAG-mediated adaptive immunity is first encountered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.