ArticleAnnals of surgery2005
Detection of hematogenous tumor cell dissemination predicts tumor relapse in patients undergoing surgical resection of colorectal liver metastases.
Article in Annals of surgery, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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46 citing papers in PubMed, 1 synthesis or guideline pooled it, 120 citations in OpenAlex.
- Meta-analysis of the effect of the pringle maneuver on long-term oncological outcomes following liver resection.Scientific reports · 2021Pooled it
- Presence of bone marrow micro-metastases in stage I-III colon cancer patients is associated with worse disease-free and overall survival.Cancer medicine · 2017Trial
- Trial
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- Primary-Site Local Therapy for Patients with De Novo Metastatic Breast Cancer: An Educational Review.Annals of surgical oncology · 2022Review
- Pleiotropic Roles of Atrial Natriuretic Peptide in Anti-Inflammation and Anti-Cancer Activity.Cancers · 2022Review
- Targeting HECTD3-IKKα axis inhibits inflammation-related metastasis.Signal transduction and targeted therapy · 2022Article
- Long-term survival differences between sevoflurane and propofol use in general anesthesia for gynecologic cancer surgery.Journal of anesthesia · 2021Article
- The essential role of PRAK in tumor metastasis and its therapeutic potential.Nature communications · 2021Article
- Association between perioperative glucocorticoids and cancer metastasis and survival in patients undergoing radical cystectomy for urothelial carcinoma of the bladder: A single-center retrospective study.Investigative and clinical urology · 2020Article
- Observational
- Detection of circulating tumor cells and circulating tumor DNA before and after mammographic breast compression in a cohort of breast cancer patients scheduled for neoadjuvant treatment.Breast cancer research and treatment · 2019Article
- Anterior Approach to Major Resection for Colorectal Liver Metastasis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2018Article
- Identifying patients with an unfavorable prognosis in early stages of colorectal carcinoma.Oncotarget · 2018Article
- Surgery for Cancer: A Trigger for Metastases.Cancer research · 2017Review
- Circulating tumor cells: what we know, what do we want to know about them and are they ready to be used in clinics?American journal of translational research · 2017Article
- Molecular markers of prognosis and therapeutic targets in metastatic colorectal cancer.Surgical oncology · 2016Review
- Can the prognosis of colorectal cancer be improved by surgery?World journal of gastrointestinal surgery · 2016Review
- Circulating tumor cells exhibit stem cell characteristics in an orthotopic mouse model of colorectal cancer.Oncotarget · 2016Article
- Lack of Impact of Robotic Assisted Laparoscopic Radical Prostatectomy on Intraoperative Levels of Prostate Cancer Circulating Tumor Cells.The Journal of urology · 2016Article
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine the prognostic significance of disseminated tumor cells in blood and bone marrow of patients undergoing surgical resection of colorectal liver metastases. SUMMARY BACKGROUND DATA: Despite curative hepatic resection of colorectal liver metastases, a high percentage of patients develop tumor recurrence. These recurrences probably originate from disseminated tumor cells released into the circulation before or during surgery.
methodsThirty-seven patients with potentially curative (R0) resection of colorectal liver metastases were prospectively enrolled into the study. Preoperative bone marrow samples and preoperative, intraoperative, and postoperative blood samples were examined for disseminated tumor cells by CK20 RT-PCR.
resultsTumor cells were detected in preoperative blood samples in 11 of 37 (30%) patients, in intraoperative blood samples in 17 of 37 (46%) patients, and in postoperative blood samples in 8 of 37 (22%) patients. Four of 25 (16%) patients tested positive for disseminated tumor cells in bone marrow samples. Median follow-up time for all patients was 38 months (range, 10-63 months). Multivariate analysis confirmed tumor cell detection in intraoperative blood (P = 0.009) and in bone marrow samples (P = 0.013) to be independent prognostic factors of tumor relapse.
conclusionsThis is the first study demonstrating that detection of hematogenous tumor cell dissemination during hepatic resection of colorectal cancer metastases predicts tumor relapse. Detection of disseminated tumor cells may help to individualize adjuvant therapy for patients with colorectal liver metastases and to develop surgical strategies to prevent intraoperative hematogenous tumor cell shedding.
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