ArticleAIDS research and human retroviruses2004
Complete genome analysis of one of the earliest SIVcpzPtt strains from Gabon (SIVcpzGAB2).
Article in AIDS research and human retroviruses, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- CD4 receptor diversity in chimpanzees protects against SIV infection.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- High Rate of Simian Immunodeficiency Virus (SIV) Infections in Wild Chimpanzees in Northeastern Gabon.Viruses · 2015Article
- Neutralization properties of simian immunodeficiency viruses infecting chimpanzees and gorillas.mBio · 2015Article
- Origin of the HIV-1 group O epidemic in western lowland gorillas.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Budding of retroviruses utilizing divergent L domains requires nucleocapsid.Journal of virology · 2012Article
- New strain of simian immunodeficiency virus identified in wild-born chimpanzees from central Africa.PloS one · 2012Article
- Molecular epidemiology of simian immunodeficiency virus infection in wild-living gorillas.Journal of virology · 2010Article
- Effective activation alleviates the replication block of CCR5-tropic HIV-1 in chimpanzee CD4+ lymphocytes.Virology · 2009Article
- The inability to disrupt the immunological synapse between infected human T cells and APCs distinguishes HIV-1 from most other primate lentiviruses.The Journal of clinical investigation · 2009Article
- Origin and biology of simian immunodeficiency virus in wild-living western gorillas.Journal of virology · 2009Article
- Primate lentivirus capsid sensitivity to TRIM5 proteins.Journal of virology · 2008Article
- Adaptation of HIV-1 to its human host.Molecular biology and evolution · 2007Article
- Going wild: lessons from naturally occurring T-lymphotropic lentiviruses.Clinical microbiology reviews · 2006Review
- Simian immunodeficiency virus infection of chimpanzees.Journal of virology · 2005Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Chimpanzees in west central Africa (Pan troglodytes troglodytes) are known to harbor simian immunodeficiency viruses (SIVcpzPtt) that represent the closest relatives of human immunodeficiency virus type 1 (HIV-1); however, the number of SIVcpzPtt strains that have been fully characterized is still limited. Here, we report the complete nucleotide sequence of SIVcpzGAB2, a virus originally identified in 1989 in a chimpanzee (P. t. troglodytes) from Gabon. Analysis of this sequence reveals that SIVcpzGAB2 is a member of the SIVcpzPtt group of viruses, but that it differs from other SIVcpzPtt strains by exhibiting a highly divergent Env V3 loop with an unusual crown (NLSPGTT) containing a canonical N-linked glycosylation site, an unpaired cysteine residue in Env V4, and two late (L) domain motifs (PTAP and YPSL) in Gag p6. Moreover, phylogenetic analyses indicate evidence of recombination during the early divergence of SIVcpzPtt strains; in particular, part of the pol gene sequence of SIVcpzGAB2 appears to be derived from a previously unidentified SIVcpz lineage ancestral to HIV-1 group O. These data indicate extensive diversity among naturally occurring SIVcpzPtt strains and provide new insight into the origin of HIV-1 group O.
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