ArticleJournal of virology2005
Evidence for heterogeneous selective pressures in the evolution of the env gene in different human immunodeficiency virus type 1 subtypes.
Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- HIV RNA Rebound in Seminal Plasma after Antiretroviral Treatment Interruption.Journal of virology · 2020Trial
- Short Communication: A Recombinant Variant with Increased Envelope Entry Efficiency Emerged During Early Infection of an HIV-1 Subtype C Dual Infected Rapid Progressor.AIDS research and human retroviruses · 2016Trial
- Consequences of HIV infection in the bone marrow niche.Frontiers in immunology · 2023Review
- Variation of natural selection in the Amoebozoa reveals heterogeneity across the phylogeny and adaptive evolution in diverse lineages.Frontiers in ecology and evolution · 2022Article
- Analysis of sequence diversity and selection pressure in HIV-1 clade C gp41 from India.Virusdisease · 2020Article
- HIV persists throughout deep tissues with repopulation from multiple anatomical sources.The Journal of clinical investigation · 2020Article
- Differential selection in HIV-1 gp120 between subtype B and East Asian variant B'.Virologica Sinica · 2014Article
- HIV-1 diversity in the envelope glycoproteins: implications for viral entry inhibition.Viruses · 2013Review
- Positive selection in the hemagglutinin-neuraminidase gene of Newcastle disease virus and its effect on vaccine efficacy.Virology journal · 2011Article
- Constraints on HIV-1 diversity from protein structure.Journal of virology · 2010Article
- Complex positive selection pressures drive the evolution of HIV-1 with different co-receptor tropisms.Science China. Life sciences · 2010Article
- T-cell vaccine strategies for human immunodeficiency virus, the virus with a thousand faces.Journal of virology · 2009Review
- Appreciating HIV type 1 diversity: subtype differences in Env.AIDS research and human retroviruses · 2009Article
- Non-random pre-transcriptional evolution in HIV-1. A refutation of the foundational conditions for neutral evolution.Genetics and molecular biology · 2009Article
- Conserved positive selection signals in gp41 across multiple subtypes and difference in selection signals detectable in gp41 sequences sampled during acute and chronic HIV-1 subtype C infection.Virology journal · 2008Article
- Evolutionary modeling of rate shifts reveals specificity determinants in HIV-1 subtypes.PLoS computational biology · 2008Article
- Reducing the false positive rate in the non-parametric analysis of molecular coevolution.BMC evolutionary biology · 2008Article
- Diversifying selection and host adaptation in two endosymbiont genomes.BMC evolutionary biology · 2007Article
- Bursts of nonsynonymous substitutions in HIV-1 evolution reveal instances of positive selection at conservative protein sites.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Adaptation to different human populations by HIV-1 revealed by codon-based analyses.PLoS computational biology · 2006Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have demonstrated the emergence of human immunodeficiency virus type 1 (HIV-1) subtypes with various levels of fitness. Using heterogeneous maximum-likelihood models of adaptive evolution implemented in the PAML software package, with env sequences representing each HIV-1 group M subtype, we examined the various intersubtype selective pressures operating across the env gene. We found heterogeneity of evolutionary mechanisms between the different subtypes with a category of amino acid sites observed that had undergone positive selection for subtypes C, F1, and G, while these sites had undergone purifying selection in all other subtypes. Also, amino acid sites within subtypes A and K that had undergone purifying selection were observed, while these sites had undergone positive selection in all other subtypes. The presence of such sites indicates heterogeneity of selective pressures within HIV-1 group M subtype evolution that may account for the various levels of fitness of the subtypes.
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