ArticleGenes & development2005
Foxl1 is a mesenchymal Modifier of Min in carcinogenesis of stomach and colon.
Article in Genes & development, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 79 citations in OpenAlex.
- Villification of the intestinal epithelium is driven by Foxl1 through activation of PDGFRα and BMPs.Nature communications · 2026Article
- Integrative transcriptomic and single-cell analysis reveals mitochondrial-related gene biomarkers in heart failure with preserved ejection fraction.Scientific reports · 2025Article
- Regulation of intestinal epithelial homeostasis by mesenchymal cells.Inflammation and regeneration · 2024Review
- A dual sgRNA library design to probe genetic modifiers using genome-wide CRISPRi screens.BMC genomics · 2023Article
- MethReg: estimating the regulatory potential of DNA methylation in gene transcription.Nucleic acids research · 2022Article
- BMI1 governs the maintenance of mouse GC-2 cells through epigenetic repression ofAmerican journal of translational research · 2022Article
- Article
- Prognostic Significances of NEDD-9 and FOXL-1 Expression in Intestinal Type Gastric Carcinoma: an Immunohistochemical Study.Journal of gastrointestinal cancer · 2021Article
- MicroRNA-188-5p targeting Forkhead Box L1 promotes colorectal cancer progression via activating Wnt/β-catenin signaling.Oncology research · 2021Article
- FOXL1 overexpression is associated with poor outcome in patients with glioma.Oncology letters · 2019Article
- Dual-specificity phosphatase 6 deletion protects the colonic epithelium against inflammation and promotes both proliferation and tumorigenesis.Journal of cellular physiology · 2019Article
- Article
- The Emerging Roles of Forkhead Box (FOX) Proteins in Osteosarcoma.Journal of Cancer · 2017Review
- SHP-2 phosphatase contributes to KRAS-driven intestinal oncogenesis but prevents colitis-associated cancer development.Oncotarget · 2016Article
- Loss of mesenchymal bone morphogenetic protein signaling leads to development of reactive stroma and initiation of the gastric neoplastic cascade.Scientific reports · 2016Article
- Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth.Nature communications · 2016Article
- Low level of FOXL1 indicates a worse prognosis for gastric cancer patients.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- DNA Hypomethylation Contributes to Genomic Instability and Intestinal Cancer Initiation.Cancer prevention research (Philadelphia, Pa.) · 2016Article
- Foxl1-expressing mesenchymal cells constitute the intestinal stem cell niche.Cellular and molecular gastroenterology and hepatology · 2016Article
- Screening Driving Transcription Factors in the Processing of Gastric Cancer.Gastroenterology research and practice · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Constitutive activation of the Wnt/APC/beta-catenin pathway is a frequent initiating event in gastrointestinal carcinogenesis. Mutations in the Adenomatous Polyposis Coli (APC) gene up-regulate Wnt signaling by stabilizing beta-catenin and causing activation of targets important in proliferation control. Here we show that loss of the mesenchymal transcription factor Foxl1 leads to a marked increase in tumor multiplicity in the colon of Apc(Min) mice. Apc(Min/+);Foxl1-/- mice also develop gastric tumors not observed in Apc(Min) mice. These effects are caused by earlier tumor initiation due to accelerated loss of heterozygosity (LOH) at the Apc locus. Foxl1 is the first mesenchymal Modifier of Min and plays a key role in gastrointestinal tumorigenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.