ArticleThe Journal of physiology2005
Role of the transient outward current (Ito) in shaping canine ventricular action potential--a dynamic clamp study.
Article in The Journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Alumina nanoparticles-induced reduction in Ito, f contributes to the occurrence of ventricular arrhythmias.BMC cardiovascular disorders · 2026Article
- Role of natural inter-individual variability in the different penetrance of congenital long QT syndromes (LQTS) types 1 and 2: an in silico approach.Scientific reports · 2026Article
- Acute exposure to low-dose bisphenol A delays cardiac repolarization in female canine heart - Implication for proarrhythmic toxicity in large animals.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2023Article
- Improved CaJournal of molecular and cellular cardiology · 2022Article
- The HVCN1 voltage-gated proton channel contributes to pH regulation in canine ventricular myocytes.The Journal of physiology · 2022Article
- Research Advances on Matrine.Frontiers in chemistry · 2022Review
- Sigma-1 receptor ligands improves ventricular repolarization-related ion remodeling in rats with major depression disorder.Psychopharmacology · 2021Article
- Chronic Sympathetic Hyperactivity Triggers Electrophysiological Remodeling and Disrupts Excitation-Contraction Coupling in Heart.Scientific reports · 2020Article
- A microtranslatome coordinately regulates sodium and potassium currents in the human heart.eLife · 2019Article
- Memory-induced nonlinear dynamics of excitation in cardiac diseases.Physical review. E · 2018Article
- Differential Expression and Remodeling of Transient Outward Potassium Currents in Human Left Ventricles.Circulation. Arrhythmia and electrophysiology · 2018Article
- The IK1/Kir2.1 channel agonist zacopride prevents and cures acute ischemic arrhythmias in the rat.PloS one · 2017Article
- Effects of allocryptopine on outward potassium current and slow delayed rectifier potassium current in rabbit myocardium.Journal of geriatric cardiology : JGC · 2016Article
- Hydrogen Sulfide Targets the Cys320/Cys529 Motif in Kv4.2 to Inhibit the Ito Potassium Channels in Cardiomyocytes and Regularizes Fatal Arrhythmia in Myocardial Infarction.Antioxidants & redox signaling · 2015Article
- Distinctive electrophysiological characteristics of right ventricular out-flow tract cardiomyocytes.Journal of cellular and molecular medicine · 2014Article
- Dependence of phase-2 reentry and repolarization dispersion on epicardial and transmural ionic heterogeneity: a simulation study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2014Article
- Stabilization of Kv4 protein by the accessory K(+) channel interacting protein 2 (KChIP2) subunit is required for the generation of native myocardial fast transient outward K(+) currents.The Journal of physiology · 2013Article
- Functional integrity of the T-tubular system in cardiomyocytes depends on p21-activated kinase 1.Journal of molecular and cellular cardiology · 2013Article
- Differential effects of the peroxynitrite donor, SIN-1, on atrial and ventricular myocyte electrophysiology.Journal of cardiovascular pharmacology · 2013Article
- MATLAB implementation of a dynamic clamp with bandwidth of >125 kHz capable of generating I Na at 37 °C.Pflugers Archiv : European journal of physiology · 2013Article
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Abstract
Transmural electrical dispersion determines the repolarization sequence across the ventricular wall, and plays an important role in the development of arrhythmias under pathological conditions. While it is clear that the transmural gradient of the transient outward current (I(to)) underlies the dramatic difference in phase 1 repolarization across the ventricle, its contribution to the transmural action potential duration (APD) dispersion is not clear. We investigated this problem using the dynamic clamp technique in canine ventricular myocytes. The dynamic clamp allows quantitative 'insertion' of simulated conductances in real, biological cells, bridging pure computer modelling and experimental electrophysiology. 'Insertion' of an epicardial level of I(to) in endocardial cells produced a prominent phase 1 repolarization and a 'spike-and-dome' action potential morphology, but did not significantly affect the APD. Increasingly larger I(to) densities prolonged, and then dramatically shortened the endocardial APD. We also used the dynamic clamp to subtract, or 'block' the native I(to) in epicardial cells. Such 'blockade' eliminated the epicardial action potential notch, but had no significant effect on the APD. We conclude that I(to), while being a key regulator of phase 1 repolarization, does not significantly affect the APD of canine ventricular myocytes, and that the I(to) gradient is not a significant contributor to the transmural APD dispersion in the canine ventricle. By allowing computer simulation on a biological background, the dynamic clamp is a new and effective tool to study the ionic basis of the electrical properties of cardiac cells.
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