ArticleDevelopmental biology2005
Rho1 regulates signaling events required for proper Drosophila embryonic development.
Article in Developmental biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Centralspindlin proteins Pavarotti and Tumbleweed along with WASH regulate nuclear envelope budding.The Journal of cell biology · 2023Article
- Article
- RpS13 controls the homeostasis of germline stem cell niche through Rho1-mediated signals in the Drosophila testis.Cell proliferation · 2020Article
- Article
- Wash functions downstream of Rho1 GTPase in a subset of Drosophila immune cell developmental migrations.Molecular biology of the cell · 2015Article
- Gene co-citation networks associated with worker sterility in honey bees.BMC systems biology · 2014Article
- Extensive differences in antifungal immune response in two Drosophila species revealed by comparative transcriptome analysis.International journal of genomics · 2013Article
- Drosophila embryos close epithelial wounds using a combination of cellular protrusions and an actomyosin purse string.Journal of cell science · 2012Article
- Rho GTPase controls Drosophila salivary gland lumen size through regulation of the actin cytoskeleton and Moesin.Development (Cambridge, England) · 2011Article
- Cell wound repair in Drosophila occurs through three distinct phases of membrane and cytoskeletal remodeling.The Journal of cell biology · 2011Article
- Article
- Genetic screen in Drosophila melanogaster uncovers a novel set of genes required for embryonic epithelial repair.Genetics · 2010Article
- A second-site noncomplementation screen for modifiers of Rho1 signaling during imaginal disc morphogenesis in Drosophila.PloS one · 2009Article
- Wash functions downstream of Rho and links linear and branched actin nucleation factors.Development (Cambridge, England) · 2009Article
- Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migration.The Journal of cell biology · 2005Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The Rho small GTPase has been implicated in many cellular processes, including actin cytoskeletal regulation and transcriptional activation. The molecular mechanisms underlying Rho function in many of these processes are not yet clear. Here we report that in Drosophila, reduction of maternal Rho1 compromises signaling pathways consistent with defects in membrane trafficking events. These mutants fail to maintain expression of the segment polarity genes engrailed (en), wingless (wg), and hedgehog (hh), contributing to a segmentation phenotype. Formation of the Wg protein gradient involves the internalization of Wg into vesicles. The number of these Wg-containing vesicles is reduced in maternal Rho1 mutants, suggesting a defect in endocytosis. Consistent with this, stripes of cytoplasmic beta-catenin that accumulate in response to Wg signaling are narrower in these mutants relative to wild type. Additionally, the amount of extracellular Wg protein is reduced in maternal Rho1 mutants, indicating a defect in secretion. Signaling pathways downregulated by endocytosis, such as the epidermal growth factor receptor (EGFR) and Torso pathways, are hyperactivated in maternal Rho1 mutants, consistent with a general role for Rho1 in regulating signaling events governing proper patterning during Drosophila development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.