ArticleNucleic acids research2005
The RNA ligands for mouse proline-rich RNA-binding protein (mouse Prrp) contain two consensus sequences in separate loop structure.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
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- pH dependence of C•A, G•A and A•A mismatches in the stem of precursor microRNA-31.Biophysical chemistry · 2022Article
- Specific autoantigens identified by sera obtained from mice that are immunized with testicular germ cells alone.Scientific reports · 2016Article
- Rice MEL2, the RNA recognition motif (RRM) protein, binds in vitro to meiosis-expressed genes containing U-rich RNA consensus sequences in the 3'-UTR.Plant molecular biology · 2015Article
- The splicing activator DAZAP1 integrates splicing control into MEK/Erk-regulated cell proliferation and migration.Nature communications · 2014Article
- DAZAP1 regulates the splicing of Crem, Crisp2 and Pot1a transcripts.Nucleic acids research · 2013Article
- Article
- Protein acetylation and spermatogenesis.Reproductive system & sexual disorders : current research · 2013Article
- A biophysical model for identifying splicing regulatory elements and their interactions.PloS one · 2013Article
- Bioinformatic identification of novel elements potentially involved in messenger RNA fate control during spermatogenesis.Biology of reproduction · 2012Article
- DAZAP1, an RNA-binding protein required for development and spermatogenesis, can regulate mRNA translation.RNA (New York, N.Y.) · 2011Article
- Structural characterization of naturally occurring RNA single mismatches.Nucleic acids research · 2011Article
- Transcription and post-transcriptional regulation of spermatogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- RNA recognition by the embryonic cell fate determinant and germline totipotency factor MEX-3.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Retinoic acid-gated sequence-specific translational control by RARalpha.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Automatic detection of exonic splicing enhancers (ESEs) using SVMs.BMC bioinformatics · 2008Article
- DAZAP1, an hnRNP protein, is required for normal growth and spermatogenesis in mice.RNA (New York, N.Y.) · 2008Article
- Binding of DAZAP1 and hnRNPA1/A2 to an exonic splicing silencer in a natural BRCA1 exon 18 mutant.Molecular and cellular biology · 2008Article
- A novel nucleocytoplasmic shuttling sequence of DAZAP1, a testis-abundant RNA-binding protein.RNA (New York, N.Y.) · 2006Article
- 40LoVe interacts with Vg1RBP/Vera and hnRNP I in binding the Vg1-localization element.RNA (New York, N.Y.) · 2006Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mouse proline-rich RNA-binding protein (mPrrp) is a mouse ortholog of Xenopus Prrp, which binds to a vegetal localization element (VLE) in the 3'-untranslated region (3'-UTR) of Vg1 mRNA and is expected to be involved in the transport and/or localization of Vg1 mRNA to the vegetal cortex of oocytes. In mouse testis, mPrrp protein is abundantly expressed in the nuclei of pachytene spermatocytes and round spermatids, and shifts to the cytoplasm in elongating spermatids. To gain an insight into the function of mPrrp in male germ cells, we performed in vitro RNA selection (SELEX) to determine the RNA ligand sequence of mPrrp. This analysis revealed that many of the selected clones contained both of two conserved elements, AAAUAG and GU1-3AG. RNA-binding study on deletion mutants and secondary structure analyses of the selected RNA revealed that a two-loop structure containing the conserved elements is required for high-affinity binding to mPrrp. Furthermore, we found that the target mRNAs of Xenopus Prrp contain intact AAAUAG and GU1-3AG sequences in the 3'-UTR, suggesting that these binding sequences are shared by Prrps of Xenopus and mouse.
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